SynthesisJournal of medical virology2025
Systematic Review and Meta-Analysis of the Association Between Clinical Severity and Co-Infection of Human Adenovirus With Other Respiratory Pathogens in Children.
Synthesis in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Clinical differentiation between pediatric pulmonary tuberculosis andExperimental and therapeutic medicine · 2026Review
- Clinical characteristics and predictors of severe pertussis in hospitalized children after the COVID-19 period in Türkiye: a multicenter study.European journal of pediatrics · 2026Article
- Epidemiology, bacterial coinfection risk factors, and inflammatory markers in children with RSV, AdV, and hMPV pneumonia in Zunyi, China.BMC infectious diseases · 2026Article
- Viral-bacterial codetection and clinical and laboratory characteristics in children hospitalized with lower respiratory tract infections in a private hospital in Lima, Peru: a cross-sectional study.Tropical diseases, travel medicine and vaccines · 2026Article
- Common respiratory virus spectrum and epidemiological trends among children in Northwest China during the post-COVID-19 era.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Pediatric adenovirus infections: 10-year clinical spectrum and predictors of severe disease with emphasis on comorbidities and coinfections.European journal of pediatrics · 2026Observational
- Microbial spectrum, co-detection patterns, and clinical correlations in 10,153 hospitalized children with acute respiratory infections: a large-scale tNGS analysis.Journal of translational medicine · 2026Article
- The changed endemic pattern of human adenovirus from species C to B among children in 2022-2024 in Shenzhen, China.Scientific reports · 2026Article
- Application of metagenomic next-generation sequencing in children with pneumonia of unknown etiology.Frontiers in cellular and infection microbiology · 2026Article
- First identification of human adenovirus subtype 21a in Shenzhen, China with high-throughput sequencing.Frontiers in microbiology · 2025Article
- Seasonal dynamics and genetic diversity of human adenoviruses in patients with acute respiratory infection in Thailand, 2024.PloS one · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
The correlation between the co-infection of human respiratory adenovirus (HAdV) and clinical severity has not been firmly established yet. We carried out a systematic review and meta-analysis. We scoured six databases for studies published up to 16 May 2024. A total of 66 cohort studies, which involved 16 251 participants, were incorporated. When compared with patients suffering from HAdV single infection, those with co-infection of viruses (risk ratios [RRs] = 1.40, 95% confidence interval [CI]: 1.05-1.86), bacteria (RR = 1.50, 95% CI: 1.05-2.16), or fungi (RR = 2.86, 95% CI: 2.17-3.76) were more prone to experience severe clinical outcomes. Co-infection with Mycoplasma pneumoniae had a tendency to elevate the risk of common pneumonia (RR = 1.81, 95% CI: 1.66-1.97), and bacterial co-infection was likely to extend the hospital stay (mean differences = 2.23 days, 95% CI: 0.44-4.03). In summary, the co-infection of HAdV with other viral, bacterial, fungal respiratory pathogens or Mycoplasma pneumoniae heightened the risk of severe clinical outcomes in pediatric patients, leading to an increased utilization of medical resources. This implied that the ecological and biological mechanisms underlying the potential interactions between HAdV and other microorganisms merited further investigation.
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