ArticleFrontiers in neurology2025
Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic potential of near-infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource-limited settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Correlation of prefrontal-based resting state functional connectivity with the degree of cognitive impairment in Alzheimer's disease: a functional near-infrared spectroscopy study.Behavioral and brain functions : BBF · 2025Article
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5 authors.
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Abstract
Objective: The most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body dementia (LBD), and they have overlapping clinical symptoms. We aimed to define amounts of cortical activation and to identify indicators of brain function to better distinguish between these types of dementia and aid diagnosis using functional near-infrared spectroscopy (fNIRS). Methods: Oxygenated hemoglobin (HbO) concentrations in the brains of patients with AD and LBD were detected using fNIRS. Brain function was assessed using a verbal fluency task (VFT). Resting-state and task-state cortical activations were investigated to determine differences between AD and LBD. Blood samples were analyzed to identify relevant biomarkers. The clinical and HbO variables were compared between AD and LBD. Functional connectivity at rest and correlations between HbO variables and blood biomarkers were analyzed. The sensitivity and specificity of the parameters for differentiating the dementias were evaluated using areas under the receiver operating characteristic (ROC) curves (AUCs). Results: This study recruited 28 inpatients with AD and 25 with LBD. Mean HbO concentrations did not significantly differ in the resting state ( Conclusion: The characteristics of HbO measured using fNIRS can help distinguish AD from LBD in older adults.
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