Increased Stress Hyperglycemia Ratio Predicts Poor Clinical Outcome in Critically Ill COPD Patients: A Retrospective Study.

Objective: Stress hyperglycemia ratio (SHR) was introduced as an indicator of relative hyperglycaemia and is widely used for prognostic prediction in critically ill patients. The present study aimed to investigate the relationship between SHR and adverse clinical outcomes in critically ill COPD patients. Methods: A total of 1,580 patients diagnosed with COPD were included in this retrospective cohort study. SHR = ABG (mmol/L) / [1.59 × HbA1c (%) - 2.59]. Primary endpoints included ICU mortality and in-hospital mortality. Secondary endpoints were acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute respiratory failure (ARF). Logistic regression, Restricted Cubic Sample (RCS) and Receiver Operating Characteristic (ROC) were used to explore the relationship between SHR and prognosis of COPD patients. In addition, subgroup analyses and interaction tests were performed to investigate potential heterogeneity. Results: Multivariate logistic regression analysis showed that elevated SHR was not associated with ICU mortality and in-hospital mortality. In contrast, SHR quartiles were correlated with ICU mortality and in-hospital mortality. Restricted cubic spline regression models showed a nonlinear correlation between SHR and both ICU mortality and in-hospital mortality (all Conclusion: SHR is independently associated with an increased risk of adverse clinical outcomes in critically ill COPD patients.