ArticleBrain, behavior, & immunity - health2025
Social relationships and immune aging in early midlife: Evidence from the National Longitudinal Study of Adolescent to Adult Health.
Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Inflammation and Perceived Social Support in Elite Athletes (A Quantile Regression Approach).Neuroimmunomodulation · 2026Article
- Relationship stress and epigenetic age acceleration among older U.S. adults in the Midlife in the United States study.Epigenomics · 2025Article
- Influence of senescence on the sensitization potential of chemicals detected by local lymph node assays in aged mice.Toxicology research · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Aging of the immune system is characterized by changes in the T-cell compartment, including a decrease in naïve T-cells and an increase in memory T-cells. Stress exposures are known to predict accelerated immune aging in older adults. However, social relationships, which are often linked to stress mechanisms, have not been widely studied in relation to these adaptive immune biomarkers, particularly in younger populations. We examined associations between social relationships, in terms of quantity (Social Network Index, Close Contacts Index) and quality of relationships (spouse/partner, friends, and family members), and immune aging in a U.S-representative early midlife population (age 33-44) from Wave V of the National Longitudinal Study of Adolescent to Adult Health (n = 4451). DNA methylation data of venous blood samples collected during Wave V were used to compute CD4
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Registered trials
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