ArticleApplied magnetic resonance2025
Robustness and Sensitivity of Gd(III)-Gd(III) Double Electron-Electron Resonance (DEER) Measurements: Comparative Study of High-Frequency EPR Spectrometer Designs and Spin Label Variants.
Article in Applied magnetic resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Sigmatropic rearrangement enables access to a highly stable spirocyclic nitroxide for protein spin labelling.Chemical communications (Cambridge, England) · 2025Article
- Can label or protein deuteration extend the phase relaxation time of Gd(III) spin labels?Magnetic resonance (Gottingen, Germany) · 2025Article
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10 authors.
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Abstract
In this paper, we explore the robustness and sensitivity of Gd(III)-Gd(III) double electron-electron resonance (DEER) distance measurements in proteins for different spectrometer designs and three spin labels. To do this a protein was labeled at the same two positions with Gd(III) spin labels and measurements were performed on two home-built high-frequency (W-band, ~ 95 GHz) EPR spectrometers with different design approaches, and a commercial 150 W Q-band (34 GHz) spectrometer. The first W-band measurement approach uses a conventional, narrow band single mode cavity, while the second uses a broadband non-resonant induction mode sample holder. Both systems incorporate advanced arbitrary waveform generators (AWGs) that give flexibility over excitation bandwidth. We use three DOTA-like Gd(III) spin labels, Gd.C12, Gd.DO3A and Gd.L Supplementary Information: The online version contains supplementary material available at 10.1007/s00723-024-01741-0.
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