Evidence map›Paper›PMID 40297712›Full record

ArticleBrain communications2025

Ongoing loss of viable neurons for weeks after mild hypoxia-ischaemia.

Melanie A McNally, Lauren A Lau, Simon Granak, David Hike, Xiaochen Liu, Xin Yu, Rachel A Donahue, Lori B Chibnik, John V Ortiz, Alicia Che and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Melanie A McNallyDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-7119-4402
Lauren A LauDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-3312-183X
Simon GranakDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
David HikeDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02129, USA.
Xiaochen LiuDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02129, USA.
Xin YuDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02129, USA.ORCID https://orcid.org/0000-0001-9890-5489
Rachel A DonahueDepartment of Medicine, Biostatics, Massachusetts General Hospital, Boston, MA 02114, USA.
Lori B ChibnikDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-6293-806X
John V OrtizDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Alicia CheDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Raul Chavez-ValdezDepartment of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Frances J NorthingtonDepartment of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Kevin J StaleyDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.

Funding

Neuronal Ion and Volume Shifts After Acute Brain InjuryR35NS116852 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Kevin J. Staley · 2020 to 2026
$8.0M
Neuronal Seizure Burden versus Cell Death after Neonatal Brain InjuryK08NS121599 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MCNALLY, MELANIE A · 2021 to 2025
$1.0M
NINDS NIH HHS K08 NS121599NINDS NIH HHS R35 NS116852
6 · The paper itself

Abstract

Mild hypoxic-ischaemic encephalopathy is common in neonates, and there are no evidence-based therapies. By school age, 30-40% of those patients experience adverse neurodevelopmental outcomes. The nature and progression of mild injury is poorly understood. We studied the evolution of mild perinatal brain injury using longitudinal two-photon imaging of transgenic fluorescent calcium-sensitive and insensitive proteins to provide a novel readout of neuronal viability and activity at cellular resolution

Indexed as

GCaMPmild hypoxic-ischaemic injuryneocortexnetworkneuronal death

Identifiers

PMID40297712
PMCPMC12034461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.