ArticleResearch square2025
Decreased cellular excitability of pyramidal tract neurons in primary motor cortex leads to paradoxically increased network activity in simulated parkinsonian motor cortex.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Recent evidence suggests that the primary motor cortex (M1) layer 5B pyramidal tract (PT5B) neurons show a decreased intrinsic excitability in mouse models of parkinsonism, which perhaps plays an important role in the pathophysiology of parkinsonian motor symptoms. PT5B neurons project to outputs in the brainstem and the spinal cord, leading to the direct motor expression of Parkinson's disease (PD) pathology. We set out to explore how the decreased PT5B neuron excitability influences the activity patterns of the M1 network. Using NEURON/NetPyNE simulators, we implemented detailed computer simulations of PT5B neurons based on control and 6-OHDA-treated mouse slice data. We placed these PT5B cells in an
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