ArticleResearch square2025
Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy.
Wen-Tao Deng, Brooke Brothers, Emily Sechrest, Li Ma, Madyson Ashcraft, Tongju Guan, Robert Barbera, Marion Cahill, Lee Shaw, Becky Chen and 3 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors.
Brooke Brothers
Emily Sechrest
Li Ma
Madyson Ashcraft
Tongju GuanWest Vriginia University.
Robert Barbera
Marion Cahill
Lee Shaw
Becky Chen
Wolfgang BaehrUniversity of Utah.
Funding
West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0MWV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Travis Salisbury · 2012 to 2026
$61.1MWVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Dominique Bollino · 2018 to 2026
$22.4MVS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Shian Liu · 2022 to 2026
$13.9MRETINAL PHOTORECEPTOR CYCLIC GMP PHOSPHODIESTERASER01EY008123 · NEI · UNIVERSITY OF UTAH · PI BAEHR, WOLFGANG · 1990 to 2019
$7.8MPhotoreceptor neuron specific alternative splicing of messenger RNAR01EY025536 · NEI · WEST VIRGINIA UNIVERSITY · PI RAMAMURTHY, VISVANATHAN, STOILOV, PETER · 2016 to 2023
$3.3MDisease mechanisms of cone opsin mutants and treatment strategiesR01EY030056 · NEI · WEST VIRGINIA UNIVERSITY · PI DENG, WEN-TAO · 2019 to 2023
$1.9MRecombinase-free conditional knock-in through alternative splicingR21EY036144 · NEI · WEST VIRGINIA UNIVERSITY · PI STOILOV, PETER · 2024 to 2025
$418kNEI NIH HHS R01 EY008123NEI NIH HHS R01 EY025536NEI NIH HHS R01 EY030056NEI NIH HHS R21 EY036144NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM121322NIGMS NIH HHS P20 GM144230NIGMS NIH HHS U54 GM104942
6 · The paper itselfAbstract
Blue cone monochromacy (BCM) is an X-linked retinal disorder caused by mutations in the
Indexed as
AAVblue cone monochromacyC203R cone opsincone dystrophycone opsingene therapytherapeutic window
Identifiers
PMID40297680
PMCPMC12036465
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