Evidence map›Paper›PMID 40297674›Full record

ArticleAmerican journal of preventive cardiology2025

Implementation strategies for improving the care of familial hypercholesterolaemia from the International Atherosclerosis Society: next steps in implementation science and practice.

Mitchell N Sarkies, Gerald F Watts, Samuel S Gidding, Raul D Santos, Robert A Hegele, Frederick J Raal, Amy C Sturm, Khalid Al-Rasadi, Dirk J Blom, Magdalena Daccord and 11 more

Abstract read
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Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mitchell N SarkiesSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Gerald F WattsSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Samuel S GiddingDepartment of Genomic Health, Geisinger, Danville, PA, USA.
Raul D SantosLipid Clinic, Heart Institute (InCor), University of São Paulo, São Paulo, Brazil.
Robert A HegeleDepartment of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, ON, Canada.
Frederick J RaalDepartment of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Amy C Sturm23andMe, Sunnyvale, CA, USA.
Khalid Al-RasadiMedical Research Centre, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Dirk J BlomDivision of Lipidology and Cape Heart Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Magdalena DaccordFH Europe Foundation, Amsterdam, The Netherlands.
Sarah D de FerrantiDepartment of Paediatrics, Harvard Medical School, Boston, MA, USA.
Emanuela FolcoInternational Atherosclerosis Society, Milan, Italy.
Peter LibbyDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pedro MataFundación Hipercolesterolemia Familiar, Madrid, Spain.
Hapizah M NawawiInstitute of Pathology, Laboratory and Forensic Medicine (I-PPerForM) and Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Uma RamaswamiRoyal Free London NHS Foundation Trust, University College London, London, UK.
Kausik K RayImperial Centre for Cardiovascular Disease Prevention, Imperial College London, London, UK.
Shizuya YamashitaDepartment of Cardiology, Rinku General Medical Center, Osaka, Japan.
Jing PangSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Gilbert R ThompsonHammersmith Hospital, Imperial College London, London, UK.
Laney K JonesDepartment of Genomic Health, Geisinger, Danville, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial hypercholesterolaemia (FH) is the most common monogenic condition associated with premature atherosclerotic cardiovascular disease. Early detection and initiation of cholesterol lowering therapy combined with lifestyle changes improves the prognosis of patients with FH significantly. The International Atherosclerosis Society (IAS) published a new guidance for implementing best practice in the care of FH. Previous guidelines and position statements seldom provided implementation recommendations. To address this, an implementation science approach was used to generate implementation strategies for the clinical recommendations made. This process entailed the generation by consensus of strong implementation recommendations according to the Expert Recommendations for Implementing Change (ERIC) taxonomy. A total of 80 general and specific implementation recommendations were generated, addressing detection (screening, diagnosis, genetic testing and counselling) and management (risk stratification, treatment of adults or children with heterozygous or homozygous FH, therapy during pregnancy and use of apheresis) of patients with FH. We describe here the IAS guidance core implementation strategies to assist with the adoption of clinical recommendations into routine practice for at-risk patients and families worldwide. We summarise the IAS guidance core implementation strategies as operative statements.

Indexed as

Cardiovascular diseaseClinical practice guidelinesCoronary artery diseaseGeneticsHypercholesterolaemiaImplementation scienceInherited heart conditions

Identifiers

PMID40297674
PMCPMC12035916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.