ArticleFrontiers in immunology2025
Impact of alcohol consumption on outcomes and potential of immune biomarkers for postoperative complications in trauma patients.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Alcohol consumption is a significant risk factor for adverse outcomes in trauma patients. Despite this, effective predictive biomarkers for postoperative complications remain elusive. This study aims to identify potential immune system biomarkers associated with postoperative complications in trauma patients with a history of chronic alcohol consumption. Methods: A prospective cohort study was conducted on trauma patients admitted to a level 1 Trauma Center. Chronic alcohol consumption and drinking habits were assessed using the Alcohol Use Disorders Identification Test (AUDIT-C) questionnaire. Specifically, 26% of patients reported no alcohol consumption, 44% reported moderate alcohol consumption, and 30% were identified as having risky alcohol consumption. Acute systemic alcohol levels at the time of injury were not measured or considered in this study, as the focus was on chronic consumption patterns. Routine blood screening data were analyzed. Results: Except for CRP, blood values were comparable between patients with risky alcohol consumption and controls. However, CRP's ability to predict complications in patients with risky alcohol consumption remained limited (ROC-AUC = 0.6288). In order to identify other predictive markers, patients were matched based on relevant covariates in further analyses. Cytokine Array screening identified CD28, B7-1, Eotaxin-3, TIMP-1, and IL-13 as potential markers to predict complications. Verification with ELISA, however, showed that potential differences could only be detected in the control group. The discrepancies observed between cytokine array and ELISA results can be best explained by methodological differences, particularly since the serum samples were pooled for initial target screening. Additionally, variations in assay sensitivity, dynamic range, and calibration protocols contribute to these discrepancies. Discussion: These findings suggest that chronic alcohol consumption alters cytokine responses, posing challenges for identifying reliable immune biomarkers for postoperative complications. Future studies should explore alternative approaches for biomarker validation and consider individualized assessment strategies for trauma patients with alcohol consumption history.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.