Risk factors for weight gain after risk reducing salpingo-oophorectomy in premenopausal patients with hereditary ovarian cancer risk.

Surabhi Tewari, Karen Hurley, Meng Yao, Snehi Shah, Melissa Yurch, Anna Chichura, Mariam AlHilli

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Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Surabhi TewariCleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Karen HurleyCenter for Adult Behavioral Health, Neurologic Institute, Cleveland Clinic, Cleveland, OH, USA.

Meng YaoDepartment of Qualitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.

Snehi ShahUniversity of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.

Melissa YurchDepartment of Subspeciality Care for Women's Health, Division of Gynecologic Oncology, 6. Obstetrics and Gynecology Institute, Cleveland Clinic, Cleveland, OH, USA.

Anna ChichuraBreast Center, Integrated Surgical Institute, Cleveland Clinic, Cleveland, OH, USA.

Mariam AlHilliDepartment of Subspeciality Care for Women's Health, Division of Gynecologic Oncology, 6. Obstetrics and Gynecology Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study examines weight changes in premenopausal patients following risk-reducing salpingo-oophorectomy (RRSO) and factors associated with postoperative weight gain. Methods: We analyzed data from premenopausal patients (age ≤ 51 years) with pathogenic variants in Results: 120 patients met inclusion criteria. Weight gain occurred in 44 (36.7 %) patients. There were no significant differences in demographic characteristics or comorbidities between groups. Preoperative weight and BMI were similar between cohorts. Mean postoperative weight and BMI were 82.4 ± 19.5 kg and 30.5 ± 6.9 kg/m Conclusions: Over one third of patients experience weight gain after RRSO. Preoperative weight and BMI did not correlate with postoperative weight gain. These data highlight the need for targeted perioperative weight management in patients undergoing RRSO.

Indexed as

MenopauseRisk-reducing salpingo-oophorectomyWeight gain

Identifiers

PMID40297563

DOI10.1016/j.gore.2025.101741

PMCPMC12036072

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