ArticleInfection and drug resistance2025
Safety and Effectiveness of Isavuconazole Treatment for Invasive Fungal Infections in Chinese Patients with Haematologic Diseases: A Case Series.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Isavuconazole for invasive mold disease in patients with hematological malignancies: a multicenter real-world study from China on efficacy, safety, and competing risks.Antimicrobial agents and chemotherapy · 2026Article
- Longitudinal changes in laboratory parameters and QTc during isavuconazole therapy in Japanese patients with hematologic malignancies.PloS one · 2026Article
- Isavuconazole in Pediatric Invasive Fungal Infections: Outcomes and Therapeutic Drug Monitoring in a Chinese Multicenter Case Series.Infection and drug resistance · 2026Article
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7 authors.
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Abstract
Objective: Isavuconazole (ISZ), a newer antifungal agent approved for treating invasive aspergillosis and mucormycosis, has been available in China since 2022. However, real-world data on ISZ use among Chinese patients with hematological diseases remain limited. In this study, we present our experience with ISZ for invasive fungal infection (IFI) management in hematology patients. Methods: Data on patient characteristics, ISZ administration variables, IFI treatment response to ISZ, and potential ISZ-associated adverse events in hematology patients from our center were retrospectively analyzed. Results: A total of 25 hematology patients treated with ISZ were included. One (4.0%) patient had proven IFI, 13 (52.0%) had probable IFI, and the remaining 11 (44.0%) were classified as having possible IFI. ISZ was used as primary therapy in 8 cases (32.0%) and salvage therapy in 17 cases (68.0%). The switch to ISZ as salvage therapy was driven by refractoriness to primary therapy in 70.6% of cases and by refractoriness and intolerance to prior antifungal treatment in 29.4%. Clinical improvement was observed in 16 (64.0%) patients. Five patients died during hospitalization, and four discontinued therapy due to clinical deterioration. Adverse events potentially attributable to ISZ occurred in 5 patients (20.0%), including nephrotoxicity, hepatotoxicity, and blurred vision (1 case each), and with the remaining two cases involving combined hepatorenal toxicity. Conclusion: ISZ demonstrates promising clinical efficacy and a favorable safety profile for IFI treatment in Chinese patients with hematologic diseases.
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