ReviewFrontiers in cell and developmental biology2025
Primordial germ cells as a potential model for understanding (Nutri) epigenetic - metabolic interactions: a mini review.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Transcriptomic changes in embryonic blood of subsequent generations following in ovo stimulation with nutriepigenetic factors.BMC genomics · 2026Article
- Transgenerational effects of in ovo stimulation with synbiotic and choline on gonadal tissue across three generations.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primordial germ cells (PGCs) are the progenitors of gametes (sperm and eggs), making them crucial for understanding germline transmission and epigenetic modifications, which are critical for studying transgenerational effects of nutrition and metabolic diseases. This is particularly relevant given the growing evidence that environmental factors, such as diet, can influence metabolic disease risk across generations through modulating epigenetic mechanisms, as seen in both human and animal studies. The unique biological and experimental attributes make PGCs in the chicken embryo a potential model for exploring the complex interactions between nutrition, epigenetic inheritance, and metabolic diseases, providing insights that are translatable to metabolic health and disease prevention tactics. This brief review emphasizes the potential of chicken PGCs as a model system to investigate the mechanisms underlying transgenerational metabolic programming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.