Evidence map›Paper›PMID 40297507›Full record

ArticlebioRxiv : the preprint server for biology2025

Ocular immune privilege in action: the living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells.

Zixuan Peng, Vijayaraj Nagarajan, Reiko Horai, Yingyos Jittayasothorn, Mary J Mattapallil, Rachel R Caspi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Zixuan PengLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Vijayaraj NagarajanLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Reiko HoraiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Yingyos JittayasothornLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Mary J MattapallilLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Rachel R CaspiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7140-7671

Funding

T-CELL LINES AND CLONES IN UVEITAZ01EY000184 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 1985 to 2008
$6.6M
Intramural NIH HHS Z01 EY000184
6 · The paper itself

Abstract

Despite ocular immune privilege, circulating retina-specific T cells can trigger autoimmune uveitis, yet intraocular bleeding-a relatively common event-rarely leads to disease. Using an in vivo immune privilege model, we previously reported that all naïve retina-specific T cells entering the eye become primed

Indexed as

autoimmune uveitisimmune toleranceOcular immune privilegesingle-cell transcriptomicsT cell anergyTregs

Identifiers

PMID40297507
PMCPMC12036435

What OpenQuestion holds

Textmetadata
LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.