Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China.

Qingyue Wu, Jingyuan Yang, Xunqiong Zhou, Mingyan Chen, Xing Yang

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Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Qingyue Wu *The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, China.

Jingyuan Yang *The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, China.

Xunqiong ZhouThe Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, China.

Mingyan ChenXingyi People's Hospital, Xingyi, China.

Xing YangSchool of Medical and Health Management, Guizhou Medical University, Guiyang, China.

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6 · The paper itself

Abstract

Background: Studies have shown that both inter-arm blood pressure difference (IABPD) and cognitive impairment are associated with vascular events. However, the relationship between IABPD and cognitive impairment among elderly individuals in rural China remains unclear. This study aims to investigate the association between IABPD and cognitive impairment in rural older adults in Guizhou, southwestern China. Methods: The study data were obtained from the Cohort Study of the Health Status of Guizhou Rural Older Adults in China (SHGROC). A multi-stage cluster sampling method was employed to select 1,088 rural elderly individuals aged ≥ 60 years from Guizhou Province for questionnaire surveys, physical examinations, and biological sample collection. Cognitive function of participants was assessed using the Mini-Mental State Examination (MMSE). Bilateral blood pressure was measured simultaneously using an automated device, and the IABPD was calculated. Multivariable linear and logistic regression models were used to examine the relationship between IABPD and cognitive impairment. Results: The overall prevalence of cognitive impairment in the study sample was 27.85%, and it was more common among participants with an IABPD ≥ 10 mmHg ( Conclusion: IASBPD ≥ 10 mmHg is associated with an increased risk of cognitive impairment in rural Chinese older adults. This suggested that IASBPD may provide a reference for early identification of individuals at risk of cognitive impairment.

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cognitive impairmentcross-sectional studyelderlyinter-arm blood pressure differencerural areas

Identifiers

PMID40297492

DOI10.3389/fnagi.2025.1489033

PMCPMC12034631

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