Evidence map›Paper›PMID 40297477›Full record

ArticleCardiovascular endocrinology & metabolism2025

Comparison of plasma metabolic profiling between children with hypertrophic obstructive cardiomyopathy and healthy controls.

Shuo Dong, Chuhao Du, Hao Cui, Jie Dong, Shun Liu, Haitao Xu, Yangxue Sun, Mengxuan Zou, Jiangping Song, Jun Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular endocrinology & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuo DongDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Chuhao DuDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Hao CuiDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Jie DongDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Shun LiuDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Haitao XuDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Yangxue SunDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Mengxuan ZouDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Jiangping SongDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.
Jun YanDepartment of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The diagnostic value of serum metabolomics in congenital heart disease has been proven. The difference of serum metabolomics between children with hypertrophic obstructive cardiomyopathy (HOCM) and normal children is unknown. Methods: Fasting blood samples of 24 symptomatic children with HOCM, 11 children with left ventricular outflow tract obstruction because of other cardiac anomalies (non-HOCM group) and 41 normal controls were obtained. The targeted metabolomic approach was performed using a Vanquish ultra-performance liquid chromatography system coupled to a Q-Exactive HF mass spectrometer. Results: The plasma level of 79 out of 224 metabolites were significantly changed (|log2FC| > 1 and Conclusion: Our results identified the significant changes of plasma metabolite between children with HOCM and healthy children, which is helpful for understanding the pathogenesis of HOCM and early diagnosis.

Indexed as

cardiovascular diseasechildrenhypertrophic obstructive cardiomyopathyliquid chromatography systemplasma metabolomics

Identifiers

PMID40297477
PMCPMC12037094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.