Evidence map›Paper›PMID 40297453›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Deep Learning Cerebellar Magnetic Resonance Imaging Segmentation in Late-Onset GM2 Gangliosidosis: Implications for Phenotype.

Connor J Lewis, Selby I Chipman, Jean M Johnston, Maria T Acosta, Cynthia J Tifft, Camilo Toro

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Connor J LewisOffice of the Clinical Director, National Human Genome Research Institute, Bethesda MD 20892 USA.ORCID 0000-0002-8204-5848
Selby I ChipmanOffice of the Clinical Director, National Human Genome Research Institute, Bethesda MD 20892 USA.
Jean M JohnstonOffice of the Clinical Director, National Human Genome Research Institute, Bethesda MD 20892 USA.
Maria T AcostaOffice of the Clinical Director, National Human Genome Research Institute, Bethesda MD 20892 USA.ORCID 0000-0001-8914-7401
Cynthia J TifftOffice of the Clinical Director, National Human Genome Research Institute, Bethesda MD 20892 USA.
Camilo ToroOffice of the Clinical Director, National Human Genome Research Institute, Bethesda MD 20892 USA.ORCID 0000-0002-3917-9031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-onset Tay-Sachs (LOTS) disease and late-onset Sandhoff disease (LOSD) have long been considered indistinguishable due to similar clinical presentations and shared biochemical deficits. However, recent magnetic resonance imaging (MRI) studies have shown distinct cerebellar atrophy associated with LOTS. In this study, we furthered this investigation to determine if the cerebellar atrophy is globally uniform or preferentially targets certain cerebellar regions. We utilized

Indexed as

Cerebellar Cortical ThicknessCerebellar SegmentationGM2 GangliosidosisLate-Onset SandhoffLate-Onset Tay-SachsNeuroimaging Biomarkers

Identifiers

PMID40297453
PMCPMC12036421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.