ArticlemedRxiv : the preprint server for health sciences2025
Effects of acute psychological stress on blood cell-free mitochondrial DNA (cf-mtDNA): A crossover experimental study.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In response to acute stress, prior studies have found an increase in circulating cell-free mitochondrial DNA (cf-mtDNA) and pro-inflammatory cytokines, highlighting two potential inter-related mechanisms by which stressors can get under the skin. However, prior studies lacked a resting control condition to isolate the effect of psychological stress from other aspects related to laboratory procedures. Here, we conducted a crossover experimental trial examining responses to a socio-evaluative stressor under laboratory conditions. 72 volunteers (age 20-50, 48% women) were tested on two occasions, counterbalanced, separated by at least a month. On one occasion, they were exposed to a 5-min socio-evaluative stressor (speech task), and on the other occasion, rested for the same period. Blood samples were obtained at 10 timepoints from pre- to 2 hours post-exposure to assess neuroendocrine (cortisol, catecholamines), pro-inflammatory cytokine (IL-6, IL-10, TNF-ɑ), and both plasma and serum cf-mtDNA responses. Compared to the control visit, the stressor significantly increased anxiety, heart rate, blood pressure, cortisol, and norepinephrine (
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