ArticlemedRxiv : the preprint server for health sciences2025
Examining the relationship between plasma pTau181 and cognitive decline, structural brain integrity, and biological ageing in midlife.
Ashleigh Barrett-Young, Erin E Cawston, Brigid Ryan, Wickliffe C Abraham, Antony Ambler, Tim Anderson, Kirsten Cheyne, Elizabeth Goodin, Sean Hogan, Renate M Houts and 13 more
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In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
23 authors.
Ashleigh Barrett-YoungDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-7466-3013 Wickliffe C AbrahamDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-9919-0622 Antony AmblerDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-7553-3632 Tim AndersonDepartment of Medicine, University of Otago, Christchurch, New Zealand.
Kirsten CheyneDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0003-1475-3639 Elizabeth GoodinDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-5082-8231 Sean HoganDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-8568-3426 David IrelandDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-7343-916X Sandhya RamrakhaDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-0383-9886 Phillipa WilsonDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-6293-9879 Richie PoultonDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-1052-4583 Reremoana TheodoreDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-1057-9859 Funding
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6MIs mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5MValidating a 3rd-generation methylation measure of accelerated aging: DunedinPoAm4xR01AG073207 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2022 to 2025
$2.9MNIA NIH HHS R01 AG032282NIA NIH HHS R01 AG049789NIA NIH HHS R01 AG073207
6 · The paper itselfAbstract
introductionAlthough plasma pTau181 has been shown to accurately discriminate patients with Alzheimer's disease from healthy older adults, its utility as a preclinical biomarker in middle-aged community-based cohorts is unclear.
methodsParticipants were members of the Dunedin Multidisciplinary Health and Development Study, a longitudinal study of 1037 people born in New Zealand in 1972-1973. Plasma pTau181, MRI-based brain structure, and DunedinPACE (an epigenetic biomarker of biological ageing) were measured at age 45; cognition was measured in childhood and age 45.
resultsWe observed a wide range of pTau181 concentrations in our same-aged sample (n=856; M=13.6pg/mL, SD=9.1pg/mL). Males had significantly higher pTau181 concentrations than females. No statistically significant associations were observed with cognitive decline, lower structural brain integrity, or accelerated biological ageing. DISCUSSION: In this midlife cohort, wide variation in pTau181 concentrations was present by age 45, but was not associated with patterns of AD-risk in cognition, brain structure, or biological ageing.
Indexed as
Alzheimer diseasebiomarkersblood biomarkersdementiadiagnosisphosphorylated tau
Identifiers
PMID40297422
PMCPMC12036385
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