Evidence map›Paper›PMID 40297371›Full record

ArticleDigital health

Development of a digital treatment analyzer for the management of prostate cancer patients, with the help of real world data and use of predictive modelling.

Lev Korolkov, Heather A Robinson, Konstantinos Mouratis

Abstract readCase Reports
In one paragraph

Article in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lev KorolkovTechnical University of Munich, Munchen, Germany.ORCID https://orcid.org/0009-0008-0752-5439
Heather A RobinsonHealth eResearch Centre, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0001-7604-2723
Konstantinos MouratisLeipzig Heart Centre University Hospital: Herzzentrum Leipzig Universitatsklinik, Leipzig, Germany.ORCID https://orcid.org/0000-0002-5216-9719

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer is the second most diagnosed cancer in the world. Treatment guidelines involve a multitude of therapies, however adherence to them is not fully established, while lack of personalized treatment strategies fails to put the patient as an individual clinical profile at the center of their treatment. We aim to present the concept of a digital treatment analyzer (TA) for the management of prostate cancer (PC) patients, leveraging real-world data (RWD) and predictive modeling to enhance personalized disease management strategies and adherence to PC guidelines, ultimately aiming to optimize therapeutic efficacy and improve outcomes. The TA comprises digital tools integrated into one user-intuitive interface, facilitating the development of patient-specific clinical profiles, classification of patients into matched historical RWD cohorts, presentation of relevant clinical guidelines, visual representation of treatment and outcomes, and mortality risk prediction based on a validated machine learning models. The Medical Information Mart for Intensive Care (MIMIC) IV dataset was utilized, including structured and unstructured data from the patient journey. The developed TA represents a promising approach to enhance personalized disease management strategies and adherence to PC guidelines. By integrating contemporary clinical guidelines, RWD and AI-driven insights, our digital TA aims to optimize therapeutic efficacy and improve patient outcomes. The presented concept demonstrates the potential for using a digital approach that integrates RWD into a treatment journey, to provide healthcare stakeholders with a holistic approach to PC management involving all available modern tools to achieve optimal outcomes.

Indexed as

Digital treatment analyzermachine learningMLmortality predictionnatural language processingNLPpersonalized disease managementpredictive modelingpropensity score matchingreal world data

Identifiers

PMID40297371
PMCPMC12034955

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.