Evidence map›Paper›PMID 40297203›Full record

ArticleTherapeutic advances in gastroenterology2025

Factors associated with failure of fecal microbiota transplant for recurrent

Joseph D K Nguyen, Kibret G Yohannes, Initha Setiady, Emma C Phillips, Rachel Ann Hays, Brian W Behm, Cirle A Warren, Jae Hyun Shin

Abstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph D K NguyenDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.ORCID https://orcid.org/0009-0008-1585-7230
Kibret G YohannesDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Initha SetiadyDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Emma C PhillipsDepartment of Internal Medicine, Ohio State University, Columbus, OH, USA.
Rachel Ann HaysDivision of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA, UAS.
Brian W BehmDivision of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA, UAS.
Cirle A WarrenDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Jae Hyun ShinInfectious Disease, Hoag Memorial Hospital Presbyterian, 1 Hoag Drive, Newport Beach, CA 92663, USA.

Funding

Alanyl-glutamine supplementation of standard treatment for C. difficile infectionR01AI145322 · NIAID · UNIVERSITY OF VIRGINIA · PI WARREN, CIRLE ALCANTARA · 2020 to 2024
$4.0M
Aging and Clostridium difficile infection: interplay of microbiota and host responseK08AG064151 · NIA · UNIVERSITY OF VIRGINIA · PI SHIN, JAE HYUN · 2019 to 2023
$801k
NIAID NIH HHS R01 AI145322NIA NIH HHS K08 AG064151
6 · The paper itself

Abstract

Background: Objectives: In this study, we seek to identify factors predictive of FMT failure. Design: Retrospective cohort study. Methods: A retrospective chart review was conducted on adult patients who were screened at the Complicated Results: In total, 240 patients underwent FMT: 70.4% were female, the median age was 68, and the median episode of CDI was 4. A total of 24.6% experienced failure within 1 year (18.3% had rCDI and 7.1% died). Age 70 or older (odds ratio (OR) = 2.66 (1.29-5.67)), ⩾4 episodes of CDI (OR = 3.13 (1.47-7.09)), and diabetes mellitus (OR = 2.82 (1.25-6.50)) were associated with failure on multivariate analysis. Conclusion: Our study shows that FMT remains an effective treatment for rCDI. We highlight several factors associated with FMT failure, such as older age, ⩾4 episodes of CDI, and diabetes mellitus, and the need for additional research to clearly define causality.

Indexed as

antimicrobialsC. difficilefecal microbiota transplantationrisk factors

Identifiers

PMID40297203
PMCPMC12035166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.