ArticleOrthopaedic journal of sports medicine2025
Effects of Silk-Elastin and SpheroSeev Mixture and Minced Cartilage on Cartilage Repair in Rabbit Osteochondral Defect Models.
Article in Orthopaedic journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reinforcement of osteochondoral defects repair with leukocyte platelet-rich fibrin and bone marrow-derived mononuclear cells in a rabbit model.BMC musculoskeletal disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Autologous chondrocyte implantation, a 2-stage, costly procedure, has limitations, prompting the development of 1-step techniques utilizing autologous minced cartilage (MC). However, novel scaffolds for cell migration and proliferation are needed to enhance their effectiveness. Purpose: To evaluate the effectiveness of silk-elastin and SpheroSeev (SESS) scaffolds in enhancing chondrocyte activity and promoting cartilage repair in a rabbit model of osteochondral defect repair. Study Design: Controlled laboratory study. Methods: The effects of a SESS mixture combined with MC on cartilage repair in osteochondral defects were investigated in 42 Japanese White rabbits, with the defect (Df) group serving as the control. Bilateral osteochondral defects were created in the knees of 36 rabbits, treated with MC, SESS, and a combination of MC and SESS, with all treated sites sealed using fibrin glue. Osteochondral cartilage repair was evaluated using the modified O'Driscoll histological scoring, immunohistochemistry for collagen type II expression, and Ki67 staining for cell proliferation at 8, 12, and 24 weeks postoperatively. Results: SESS alone and in combination with MC significantly enhanced osteochondral cartilage repair in the rabbit models by 24 weeks compared with the Df group ( Conclusion: The combined use of SESS and MC effectively promoted cartilage repair in rabbit osteochondral defects. Notably, the SESS mixture appears to enhance the structural and compositional repair of cartilage tissue, offering a promising approach for the treatment of osteochondral defects. Clinical Relevance: The novelty of this approach lies in combining silk-elastin and recombinant spider silk fibers, both of which provide mechanical support and promote cell proliferation, making them promising candidates for enhancing cartilage repair in osteochondral defects. Utilizing the SESS mixture as a scaffold for cartilage repair in osteochondral defects offers a 1-step, cost-effective alternative to traditional autologous chondrocyte implantation, potentially enhancing cartilage repair and improving tissue structure and biochemistry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.