ArticleFrontiers in public health2025
Burden of knee osteoarthritis in China and globally from 1992 to 2021, and projections to 2030: a systematic analysis from the Global Burden of Disease Study 2021.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between imbalanced lower extremity muscle quality and the development of knee osteoarthritis: a Systematic Review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Trigger Point Electrical Dry Needling with Different Waveforms Plus Intra-Articular Corticosteroid for Knee Osteoarthritis: A Prospective Randomized Controlled Trial.Journal of pain research · 2026Trial
- Synergistic Inhibition of Spinal TRPV1 Signaling by Combined Eye Acupuncture and Electroacupuncture Alleviates Inflammatory Pain in a Rat Model of Knee Osteoarthritis.Journal of pain research · 2026Article
- Type 2 Diabetes Mellitus Modifies the Association Between Exercise Therapy and Injury Risk and Long-Term Outcomes in Patients with Knee Osteoarthritis: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Altered activation patterns of sensorimotor cortex during level walking and stair climbing in patients with knee osteoarthritis: a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Lower limb biomechanics and knee tissue loading under fatigue during the badminton forward lunge in recreational female players.Frontiers in public health · 2026Article
- Metabolic pathways linking air pollution to osteoarthritis: Insights from a prospective cohort.PloS one · 2026Article
- Global, regional, and national burden of schizophrenia: epidemiological trends, decomposition, joinpoint analysis, and projections to 2036 based on GBD 2021.Frontiers in psychiatry · 2026Article
- Article
- Dynapenic abdominal obesity and symptomatic knee osteoarthritis: results from a large cross-sectional study of middle-aged and older adults in China.Annals of joint · 2026Article
- A Novel Thermosensitive Curcumin-Loaded Hydrogel That Modulates Macrophage M1/M2 Polarization for Osteoarthritis Therapy.Gels (Basel, Switzerland) · 2025Article
- TheGenes · 2025Observational
- A Wearable System for Knee Osteoarthritis: Based on Multimodal Physiological Signal Assessment and Intelligent Rehabilitation.Sensors (Basel, Switzerland) · 2025Article
- Research progress on mesenchymal stem cell‑derived exosomes in the treatment of osteoporosis induced by knee osteoarthritis (Review).International journal of molecular medicine · 2025Review
- Quality and reliability of osteoarthritis-related health information on short video platforms: a cross-sectional comparative study of TikTok and Bilibili.Frontiers in digital health · 2025Article
- Risk factors associated with knee osteoarthritis severity and their correlation with Kellgren-Lawrence grade.Frontiers in medicine · 2025Article
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6 authors.
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Abstract
Background: Knee osteoarthritis (KOA) is primarily characterized by joint pain and dysfunction, and KOA has increasingly emerged as a public health concern in China and globally. This study aims to utilize data from the Global Burden of Disease (GBD) 2021 to summarize the disease burden of KOA in China and globally from 1992 to 2021, while also predicting the disease burden in 2030. Methods: Using data from the GBD 2021 study, we compared and described the burden of KOA in China and globally. Joinpoint regression was applied to assess long-term trends in the burden of KOA based on GBD 2021 data. The impact of population growth, aging, and epidemiological trends on the burden of KOA was examined through decomposition analysis. Additionally, an age-period-cohort analysis (APC) was conducted to assess the effects of age, period, and cohort on the burden of KOA in China. Finally, we predicted the burden of KOA in 2030 using the Bayesian age-period-cohort (BAPC) and Norpred models. Results: In 2021, the number of patients with KOA in China was 10,957,472, reflecting an increase of 157.15% compared to 1992. Similarly, the incidence of KOA in China for the same year was 8,512,396, representing a rise of 123.45% since 1992. The and Years lived of disabled (YLDs) rate for KOA in China was 249.81 per 100,000 population, which is 116.44% higher than the rate observed in 1992. In 2021, the prevalence of KOA increased with age. Female exhibited higher estimates of prevalence, incidence, and YLDs than male across all age groups. Joinpoint regression analysis revealed fluctuating upward trends in prevalence, incidence, and YLDs, from 1992 to 2021. Decomposition analysis identified population growth as the primary driver of increased prevalence, incidence, and YLDs, particularly among female. Projections indicate that the number of KOA YLDs in China will continue to rise, potentially reaching a peak by 2030. Conclusion: The disease burden of KOA in China remains significant, necessitating increased attention, particularly for female and the middle-aged and older adult populations, in order to develop more targeted preventive measures.
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