Evidence map›Paper›PMID 40296917›Full record

ReviewOncology research2025

Immunomodulatory behavior of CircRNAs in tumor microenvironment.

Haisu Liang, Wei Yan, Zhi Liu, Yunbo He, Jiao Hu, Zhiwei Shu, Huihuang Li, Belaydi Othmane, Wenbiao Ren, Chao Quan and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Haisu LiangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Wei YanDepartment of Urology, Shimen Hospital of TCM, Changde, 415300, China.
Zhi LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Yunbo HeDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Jiao HuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Zhiwei ShuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Huihuang LiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Belaydi OthmaneDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Wenbiao RenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Chao QuanDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Dongxu QiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Minfeng ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Wei XiongNHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.
Bingnan ZhangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.
Peihua LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a type of non coding RNA that possess unique single stranded circular structures formed through reverse splicing mechanisms. Due to the lack of a free end that is typically susceptible to degradation by nucleases, circular RNAs exhibit resistance to ribonuclease R, making them highly stable in eukaryotic cells. The complex relationship between circRNA dysregulation and various pathophysiological conditions, especially cancer. Tumor microenvironment (TME) is a collective term for various components surrounding tumors and is an important factor affecting tumor development. Simultaneous infiltration of TME by different types of immune cells; These immune cells interact with the TME, collectively forming the so-called "tumor immune microenvironment". The complex interactions between tumor cells and TME profoundly affect the behavior of malignant tumors, and circRNAs derived from tumor cells and TME cell components have become important mediators of immune response and evasion within the TME. CircRNAs can directly or indirectly regulate immune cells, thereby modulating anti-tumor immunity. This review highlights how circRNAs, especially those encapsulated in extracellular vesicles like exosomes, influence the differentiation, chemotaxis, and anti-tumor immune functions of immune cells within the TME. Metabolic reprogramming plays an important role in this process. The process of circRNAs regulating tumor immunity is affected by multiple factors, such as hypoxia and viral infection. This review emphasizes the roles of the interaction between circRNAs and the TME in tumor immune regulation and prospects the guiding significance of circRNAs in tumor immune checkpoint therapy.

Indexed as

ImmunomodulationNeoplasmsRNA, CircularTumor MicroenvironmentAnimalsExosomesHumansRNA, CircularCircular RNA (circRNA)Immune responseMetabolic reprogrammingTumorTumor microenvironment (TME)

Identifiers

PMID40296917
PMCPMC12034001

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.