Evidence map›Paper›PMID 40296912›Full record

ReviewOncology research2025

Non-coding RNAs as potential mediators of resistance to lung cancer immunotherapy and chemotherapy.

Jiahui Wang, Hongcheng Ge, Zhengyuan Yu, Lingzhi Wu

Abstract readReview
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiahui WangDepartment of Medical Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Hongcheng GeThe First Clinical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Zhengyuan YuDepartment of Medical Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Lingzhi WuDepartment of Medical Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is a common cause of cancer-related death globally. The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy. However, as the treatment cycle progresses and the disease evolves, the emergence of acquired resistance leads to treatment failure. Many researches have shown that non-coding RNAs (ncRNAs) not only influence lung cancer progression but also act as potential mediators of immunotherapy and chemotherapy resistance in lung cancer, mediating drug resistance by regulating multiple targets and pathways. In addition, the regulation of immune response by ncRNAs is dualistic, forming a microenvironment for inhibits/promotes immune escape through changes in the expression of immune checkpoints. The aim of this review is to understand the effects of ncRNAs on the occurrence and development of lung cancer, focusing on the role of ncRNAs in regulating drug resistance of lung cancer.

Indexed as

Drug Resistance, NeoplasmImmunotherapyLung NeoplasmsRNA, UntranslatedAnimalsGene Expression Regulation, NeoplasticHumansTumor MicroenvironmentRNA, UntranslatedChemotherapyDrug resistanceImmune checkpointsImmune escapeImmunotherapyLung cancerNon-coding RNAs (ncRNAs)

Identifiers

PMID40296912
PMCPMC12034021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.