ArticleOncology research2025
The alternatively spliced diacylglycerol kinase gamma-Δ exon13 transcript generated under hypoxia promotes glioblastoma progression.
Article in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development of a diagnostic model using the circulating long noncoding RNAs LINC00857 and KLHDC7B-DT in lung adenocarcinoma.Journal of thoracic disease · 2026Article
- Multi-Omics Integration Reveals Key Genes, Metabolites and Pathways Underlying Meat Quality and Intramuscular Fat Deposition Differences Between Tibetan Pigs and Duroc × Tibetan Crossbred Pigs.Animals : an open access journal from MDPI · 2026Article
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Authors and funding
9 authors.
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Abstract
Background: Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors. Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. However, the mechanisms of hypoxia-promoted tumor progression remain elusive. Methods: Alternative splicing of diacylglycerol kinase gamma (DGKG)-Δ exon13 was amplified and verified by PCR-Sanger sequencing. The functions of DGKG and DGKG-Δ exon13 were analyzed by Cell counting kit-8 (CCK-8), Transwell, Matrigel-transwell experiments, and Results: In this study, we found that a new transcript DGKG-Δ exon13 was generated in GBM under hypoxia via alternative splicing. Moreover, the results of CCK-8, Transwell, and Matrigel-transwell experiments showed that the proliferation, migration, and invasion abilities of U87-MG and T98G were decreased after DGKG knockdown. Compared to wild-type DGKG, DGKG-Δ exon13 overexpression significantly promoted cellular proliferation, migration, and invasion abilities in GBM. Furthermore, Conclusions: Our study found that hypoxia-induced alternative splicing transcript DGKG-Δ exon13 promotes GBM proliferation and infiltration, which might provide a new potential target for the clinical treatment and diagnosis of GBM.
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