Evidence map›Paper›PMID 40296817›Full record

ArticleHistology and histopathology2025

Histological and molecular characterization of endolymphatic sac tumor reveals key differences from its primary differential diagnosis, choroid plexus papilloma.

Lea L Friker, Rebecca Klein, Ralf Clauberg, Tobias Goschzik, Julian P Layer, Ursula Gies, Michael Hölzel, Ulrich Herrlinger, Andreas Waha, Torsten Pietsch and 1 more

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Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Lea L FrikerInstitute of Neuropathology, DGNN Brain Tumor Reference Centre, University Hospital of Bonn, Bonn, Germany.
Rebecca KleinInstitute of Neuropathology, DGNN Brain Tumor Reference Centre, University Hospital of Bonn, Bonn, Germany.
Ralf ClaubergDivision of Neuroradiology, Department of Radiology, University Hospital Bonn, Bonn, Germany.
Tobias GoschzikInstitute of Neuropathology, DGNN Brain Tumor Reference Centre, University Hospital of Bonn, Bonn, Germany.
Julian P LayerInstitute of Experimental Oncology, University Hospital of Bonn, Bonn, Germany.
Ursula GiesDepartment of Neuropathology, Medical Centre Bremen-Mitte, Bremen, Germany.
Michael HölzelInstitute of Experimental Oncology, University Hospital of Bonn, Bonn, Germany.
Ulrich HerrlingerDepartment of Neurooncology, Centre for Neurology and CIO ABCD, University Hospital Bonn, Bonn, Germany.
Andreas WahaInstitute of Neuropathology, DGNN Brain Tumor Reference Centre, University Hospital of Bonn, Bonn, Germany.
Torsten PietschInstitute of Neuropathology, DGNN Brain Tumor Reference Centre, University Hospital of Bonn, Bonn, Germany.
Gerrit H GielenInstitute of Neuropathology, DGNN Brain Tumor Reference Centre, University Hospital of Bonn, Bonn, Germany.

Funding

BONFOR program of the Medical Faculty of the University of Bonn, Bonn, Germany 2022-1A-09Neuro-aCSis program, German Research Foundation (DFG) 2024-12-03
6 · The paper itself

Abstract

Endolymphatic sac tumors (ELSTs) are rare, slow-growing neoplasms of the inner ear. Microscopically, they exhibit papillary-cystic and glandular histomorphology, closely resembling their primary differential diagnosis, choroid plexus papilloma (CPP). Through in-depth histological, immunohistochemical, and molecular analysis, we identified distinct characteristics of ELST that facilitate its identification and aid in differentiating it from CPP. Immunohistochemical staining that best discriminated between ELST and CPP included EMA, S-100 protein, EpCAM, cytokeratin, transthyretin, CD34, PTEN, PAX8, and YAP. In contrast to CPP, pan-cancer DNA panel next-generation sequencing frequently revealed pathogenic

Indexed as

Ear NeoplasmsEndolymphatic SacPapilloma, Choroid PlexusAdultAgedBiomarkers, TumorDiagnosis, DifferentialFemaleHumansImmunohistochemistryMaleMiddle AgedVon Hippel-Lindau Tumor Suppressor ProteinBiomarkers, TumorVHL protein, humanVon Hippel-Lindau Tumor Suppressor Protein

Identifiers

PMID40296817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.