ArticleInternational health2025
Comparison of antimicrobial resistance genes on the ocular surface of patients with corneal infections in California and Malawi.
Article in International health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Beyond the Barrier: Overcoming Ocular Antimicrobial Resistance Through AI and Novel Therapeutics.International journal of molecular sciences · 2026Review
- Genotypic Resistance Analysis of Bacterial Species Involved in Infectious Keratitis.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundAntimicrobial resistance (AMR) determinants on the ocular surface may contribute to poor treatment responses.
methodsAn exploratory comparative analysis of ocular surface AMR determinants, as determined by RNA-sequencing (RNA-seq), on patients presenting with corneal infections at the Proctor Medical Clinic at the University of California San Francisco in San Francisco, CA, USA, and the Queen Elizabeth Central Hospital at the Department of Ophthalmology of Kamuzu College of Health Sciences in Blantyre, Malawi, was conducted. All patients underwent swabbing of three sites on the ocular surface: cornea, ipsilateral conjunctiva, and contralateral conjunctiva.
resultsMutations conferring macrolide resistance were present on the ocular surface in 58% (95% CI 44 to 71%) of the participants in Malawi and 32% (95% CI 20 to 46%) of the participants in San Francisco. Aminoglycosides resistance genes were also common on the ocular surface with 58% (95% CI 44 to 71%) prevalence in Malawi and 21% (95% CI 12 to 35%) in San Francisco. AMR was associated with poorer visual outcomes in a subset of patients.
conclusionsAs determined by RNA-seq, ocular surface AMR gene mutations are common in patients with infectious keratitis. Surveillance may be important for infectious keratitis treatment selection as well as providing guidance for antibiotic stewardship.
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