ArticleRecent advances in drug delivery and formulation2026
Lipid Microspheres for Topical Delivery of Norfloxacin: Development and Evaluation.
Article in Recent advances in drug delivery and formulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe objective of the present study was the development and evaluation of Norfloxacin lipid microspheres as topical gels for adjunct therapy to overcome complex clinical challenges presented by moist, thermally coagulated burn wounds.
methodsNorfloxacin-loaded lipid microspheres were prepared using the melt diffusion technique with Compritol ATO HD5, stearic acid, Tween 20, Span 80, and Transcutol P and incorporated into topical gels formulated with Carbopol 971P NF.
resultsThe lipid microspheres exhibited an average size of 65.22+23.39 μm and drug entrapment efficiency of 81.58 ± 0.81%. The scanning electron microscopy confirmed spherical particle morphology, while differential scanning calorimetry indicated the amorphous nature of norfloxacin within the microspheres. DISCUSSION: The melt diffusion technique yielded micron-sized spherical particles with a drug entrapment efficiency exceeding 80%.
conclusionsThe approach shows promise in enhancing Norfloxacin availability for managing burn wound complexities. However, preclinical, clinical, and regulatory evaluations are required to establish the utility of the proposed approach. Further investigations into its application for other types of chronic or infected wounds could broaden its therapeutic potential.
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