ReviewJournal of diabetes2025
Risk Factors, Pathological Changes, and Potential Treatment of Diabetes-Associated Cognitive Dysfunction.
Review in Journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Polyethylene glycol loxenatide improves cognitive and emotional performance in patients with type 2 diabetes: a 12-week multicenter clinical observational study.Journal of endocrinological investigation · 2026Article
- Development and validation of a diagnostic model for mild cognitive impairment in patients with type 2 diabetes mellitus and concomitant white matter hyperintensities.BMC neurology · 2026Article
- Solid lipid nanoparticles enhance piracetam's neuroprotective action in streptozotocin-induced cognitive dysfunction.Discover nano · 2026Article
- From the energy factory to the intercellular communication medium: the emerging role of intercellular mitochondrial transfer and mitochondrial transplantation therapy in diabetes and diabetic complications.Journal of translational medicine · 2026Review
- A review of risk factors and intervention measures for comorbidity of diabetes and mental disorders.Frontiers in psychiatry · 2026Review
- Correlation between time in range and mild cognitive impairment in older adults with type 2 diabetes mellitus.Journal of diabetes investigation · 2025Article
- Assessment of stress hyperglycemia ratio as a prognostic indicator in geriatric intensive care patients experiencing delirium: a retrospective cohort analysis.European journal of medical research · 2025Article
- Article
- Linking the heart and brain in type 2 diabetes: association between global longitudinal strain and cognitive function.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundDiabetes is a prevalent public health issue worldwide, and the cognitive dysfunction and subsequent dementia caused by it seriously affect the quality of life of patients.
methodsRecent studies were reviewed to provide a comprehensive summary of the risk factors, pathogenesis, pathological changes and potential drug treatments for diabetes-related cognitive dysfunction (DACD).
resultsSeveral risk factors contribute to DACD, including hyperglycemia, hypoglycemia, blood sugar fluctuations, hyperinsulinemia, aging, and others. Among them, modifiable risk factors for DACD include blood glucose control, physical activity, diet, smoking, and hypertension management, while non-modifiable risk factors include age, genetic predisposition, sex, and duration of diabetes. At the present, the pathogenesis of DACD mainly includes insulin resistance, neuroinflammation, vascular disorders, oxidative stress, and neurotransmitter disorders.
conclusionsIn this review, we provide a comprehensive summary of the risk factors, pathogenesis, pathological changes and potential drug treatments for DACD, providing information from multiple perspectives for its prevention and management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.