ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Surface Localized Coacervation Controlled by Bioactive Nanoarchitectonic Polyelectrolyte Multilayers.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Surface Localized Coacervation Controlled by Bioactive Nanoarchitectonic Polyelectrolyte Multilayers.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Liquid-liquid phase separation (LLPS) of biomolecules is increasingly studied in bulk conditions mainly because of its expected implication in the emergence of life. However, in living systems, the LLPS occurs also at interfaces through a precise spatiotemporal localization-induction way. Based on enzymatically active nanoarchitectured polyelectrolyte multilayer (PEM) films, a tunable stimuli-responsive surface controlling coacervation processes specifically at the solid-liquid interface is developed. Urease, embedded in multilayers, is used as a trigger to increase locally the pH near the surface in the presence of urea. The deprotonation of a short peptide synthon FFssFF occurs in close vicinity of the surface and induces the formation of FFssFF coacervate droplets at, and in, the vicinity of the surface. The variation of i) the number of enzyme layers in the PEM film, the concentration of ii) urea, or iii) coacervator impacts the kinetic, the size, and the surface density of the droplets which can result in a quasi-full covering of the surface. Based on optical and fluorescence microscopy images using a fluorescently labelled FFssFFK-Bodipy coacervator, a mechanism of the droplet's formation is established explaining the spatial localization and the control of the coacervation process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.