Evidence map›Paper›PMID 40296147›Full record

ArticleJournal of orthopaedic surgery and research2025

Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis.

Di Xue, Xiaolei Chen, Lufei Shao, Qinfu Liu, Jia Chen, Yajing Su, Chen Zhang, Zhirong Chen, Min Su, Zhiqiang Wu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Di Xue *Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, 750004, China.
Xiaolei Chen *The Orthopaedic department, General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, 750004, China.
Lufei ShaoThe Neurology department, General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, 750004, China.
Qinfu LiuThe ICU department General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Jia ChenDepartment of Orthodontics, Stomatological Hospital, General Hospital of Ningxia Medical University, 804 Shengli South Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, China.
Yajing SuNingxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, 750004, China.
Chen ZhangSchool of Education, Ningxia University, Yinchuan, 750004, Ningxia Hui Autonomous Region, China.
Zhirong ChenThe Orthopaedic department, General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, 750004, China.
Min SuDepartment of Orthopaedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Zhiqiang WuDepartment of Orthopedics, Quanzhou Orthopedic-Traumatological Hospital, Quanzhou, China.
Yiqiang YangDepartment of Orthodontics, Stomatological Hospital, General Hospital of Ningxia Medical University, 804 Shengli South Street, Yinchuan, 750004, Ningxia Hui Autonomous Region, China. 18895014581@163.com.
Xue LinNingxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, 750004, China. Lx54257@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to identify the risk factors for the progression from pulmonary tuberculosis (PTB) to spinal tuberculosis (STB), which is crucial for early disease intervention, optimizing treatment strategies, and improving patient prognosis.

methodsA retrospective analysis was conducted on 326 patients diagnosed with PTB between January 2017 and October 2024. Demographic, clinical, and socioeconomic data were collected, including age, gender, body mass index (BMI), Karnofsky Performance Status (KPS), Nutritional Risk Screening 2002 (NRS-2002) score, diabetes, per capita income, smoking status, alcohol consumption, and a history of recurrent PTB. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors for the progression to STB, and interaction effect analysis and risk stratification based on the NRS-2002 score were conducted to assess its predictive value.

resultsUnivariate logistic regression revealed that the NRS-2002 score (OR = 2.762, p < 0.001), recurrent PTB (OR = 15.370, p < 0.001), and living in relative poverty (OR = 10.000, p = 0.002) were significant risk factors for the progression from PTB to STB. Multivariate logistic regression confirmed that the NRS-2002 score (OR = 11.22, p < 0.001), recurrent PTB (OR = 5.08, p < 0.001), and living in relative poverty (OR = 2.58, p < 0.001) were independently associated with increased likelihood of STB progression. Stratified analysis revealed a clear dose-response relationship between higher NRS-2002 scores and the risk of progression to STB, with those having scores ≥ 6 exhibiting the highest odds (OR = 91.59, p < 0.001).

conclusionsThis study highlights critical risk factors for the progression from PTB to STB, particularly the NRS-2002 score, recurrent PTB, and socioeconomic status (living in relative poverty). The NRS-2002 score was identified as the most significant predictor, demonstrating a strong dose-response relationship with disease progression. Clinically, early identification of patients with elevated NRS-2002 scores, alongside timely nutritional interventions and efforts to alleviate poverty, can significantly reduce the risk of STB development. These findings can inform clinical decision-making, enhance early intervention strategies, and guide public health policies aimed at preventing STB, particularly in high-risk populations.

Indexed as

Disease ProgressionTuberculosis, PulmonaryTuberculosis, SpinalAdultAgedFemaleHumansLogistic ModelsMaleMiddle AgedRecurrenceRetrospective StudiesRisk FactorsYoung AdultLogistic regressionPulmonary tuberculosisRecurrent pulmonary tuberculosisRisk stratificationSpinal tuberculosis

Identifiers

PMID40296147
PMCPMC12036160

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.