ArticleBMC pediatrics2025
A unique case of pulmonary minimally invasive mucinous adenocarcinoma arising from atypical goblet cell hyperplasia in the bronchial epithelium of a 9-year-old girl.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- An extremely rare case of congenital pulmonary airway malformation (CPAM) and atypical adenomatous hyperplasia (AAH) with EGFR mutation in a five-year-old girl.BMC pediatrics · 2026Article
- Therapeutic dilemmas in young children with lung cancer: a case report and literature review.Frontiers in oncology · 2025Article
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Abstract
backgroundPulmonary mucinous adenocarcinoma without congenital pulmonary airway malformation (CPAM) is extremely rare in pediatric patients. Here, we report a unique case of minimally invasive mucinous adenocarcinoma without CPAM in a child and provide a comprehensive review of the clinical, radiographic, and histopathological characteristics of the published literature. CASE PRESENTATION: A 9-year-old girl presented with persistent cough and sputum production, raising suspicion of respiratory infection. Chest computed tomography (CT) revealed a solid nodule measuring 1.9 cm × 1.6 cm in the right lower lobe. Prenatal ultrasonography revealed no congenital lung abnormality. The patient subsequently underwent video-assisted thoracoscopic surgery (VATS) without postoperative complications. Histologically, a focal area demonstrated marked atypical goblet cell hyperplasia in the bronchial epithelium, which abruptly transitioned to mucinous adenocarcinoma, predominantly characterized by a lepidic growth pattern and extensive extracellular mucin accumulation. Pathological examination confirmed pulmonary minimally invasive mucinous adenocarcinoma, staged as pT1miN0M0. Next-generation sequencing (NGS) identified the KRAS G12D mutation. The patient remained well 11 months after resection and did not require additional treatment.
conclusionsWe demonstrated a novel stepwise progression originating from atypical goblet cell hyperplasia in the bronchial epithelium, rather than from the CPAM, in a pediatric patient. KRAS mutations may play a critical role in the development of pulmonary mucinous adenocarcinoma in pediatric patients.
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