Evidence map›Paper›PMID 40296037›Full record

ArticleJournal of nanobiotechnology2025

Self-healing adhesive oxidized guar gum hydrogel loaded with mesenchymal stem cell exosomes for corneal wound healing.

Ruoyan Wei, Yunzhe Wang, Ziqing Feng, Rui Liu, Chang Liu, Xiaojun Hu, Yujia Liu, Bin Kong, Xingtao Zhou, Meiyan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruoyan Wei *Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518000, Guangdong, China.
Yunzhe Wang *Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518000, Guangdong, China.
Ziqing Feng *Department of Ophthalmology, Key Lab of Myopia, Eye & ENT Hospital of Fudan University, Ministry of Health, Shanghai, 200031, China.
Rui LiuDepartment of Rheumatology and Immunology, School of Biological Science and Medical Engineering, Nanjing Drum Tower Hospital, Southeast University, Nanjing, 210096, China.
Chang LiuDepartment of Ophthalmology, Key Lab of Myopia, Eye & ENT Hospital of Fudan University, Ministry of Health, Shanghai, 200031, China.
Xiaojun HuDepartment of Ophthalmology, Key Lab of Myopia, Eye & ENT Hospital of Fudan University, Ministry of Health, Shanghai, 200031, China.
Yujia LiuDepartment of Ophthalmology, Key Lab of Myopia, Eye & ENT Hospital of Fudan University, Ministry of Health, Shanghai, 200031, China.
Bin KongDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518000, Guangdong, China. kongbin13@163.com.
Xingtao ZhouDepartment of Ophthalmology, Key Lab of Myopia, Eye & ENT Hospital of Fudan University, Ministry of Health, Shanghai, 200031, China. doctzhouxingtao@163.com.
Meiyan LiDepartment of Ophthalmology, Key Lab of Myopia, Eye & ENT Hospital of Fudan University, Ministry of Health, Shanghai, 200031, China. limeiyan0406073@126.com.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515010457National Natural Science Foundation of China 82301251, 82101184, 82371091, and 82201207Natural Science Foundation of Shanghai 23ZR1409200Project of Shanghai Xuhui District Science and Technology 2020-015, XHLHGG202104Shanghai Rising-Star Program 21QA1401500Shanghai Yangfan Project 23YF1445300Shenzhen Medical Research Fund B2401006 and A2303017
6 · The paper itself

Abstract

Hydrogels have shown great potential and value in wound healing. In this study, we construct a mesenchymal stem cell exosomes (MSC-Exos) laden natural biopolymer-based hydrogel with transparent, self-healing, injectable, and tissue adhesive properties to promote corneal regeneration. This hydrogel is synthesized by combining aldehyde-modified oxidized guar gum (OGG) and carboxymethyl chitosan (CMCS) through the dynamic, reversible Schiff base bonds, which endow it with outstanding shear-thinning and self-healing properties, facilitating easy injection through a needle. The physicochemical properties, such as porosity, mechanical strength, and light transmittance, could be precisely tunable by adjusting OGG concentrations. The resultant hydrogel achieves robust tissue adhesion at physiological temperatures due to Schiff base interactions. Besides, the Exos can be uptaken by the corneal epithelial cells and subsequently promote the migration of the cells. We have proven that the MSC-Exos-loaded hydrogel adheres firmly to the defected cornea and significantly improves wound repair by enhancing collagen deposition and reducing inflammation in a rabbit cornea defect model. These results indicated that this multifunctional hydrogel holds immense scientific promise and offers a wide range of clinical applications.

Indexed as

Corneal InjuriesExosomesGalactansHydrogelsMannansMesenchymal Stem CellsPlant GumsWound HealingAnimalsChitosanCorneaHumansOxidation-ReductionRabbitscarboxymethyl-chitosanChitosanGalactansguar gumHydrogelsMannansPlant GumsCorneaHydrogelsMesenchymal stem cell exosomesTissue adhesiveWound healing

Identifiers

PMID40296037
PMCPMC12036215

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.