ArticleReproductive biology and endocrinology : RB&E2025
Comparative analysis of endometrial gland imaging and pinopode detection for assessing endometrial receptivity.
Article in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Interconnection between polycystic ovary syndrome, immune disorders, and reproductive outcomes.Reproduction & fertility · 2026Review
- Commentary on a recent published study on endometrial receptivity assessment.Reproductive biology and endocrinology : RB&E · 2026Article
- Electroacupuncture may improve endometrial receptivity in controlled ovarian hyperstimulation mice by activating AVP neurons.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThis study aimed to obtain high-resolution endometrial gland images under high-definition hysteroscopy from in vitro fertilization and embryo transfer (IVF-ET) patients and perform image recognition to analyze their density and opening size. Concurrently, the number and morphology of pinopodes in the endometrial samples were observed using scanning electron microscopy (SEM). The objective was to compare the correlation between the two methods in evaluating endometrial receptivity and predicting pregnancy outcomes and to assess the consistency between the quantitative curves and pregnancy outcomes of the two methods in the cohort study.
methods67 patients undergoing hysteroscopic surgery who had undergone controlled ovarian hyperstimulation treatment within 1-3 menstrual cycles before the surgery were selected. Hysteroscopic exploration was performed on the 3-5 days after ovulation (during the implantation window period). Endometrial images and tissues were collected under hysteroscopy. The endometrial glands were counted, the sizes of gland openings were calculated using an image recognition algorithm, and the number and morphology of endometrial pinopodes were observed through SEM. All patients underwent embryo transfer surgery within 1-3 menstrual cycles after hysteroscopy. Patients were divided into pregnancy and non-pregnancy groups based on pregnancy outcomes. The density and size of endometrial glands, as well as the number and morphology of pinopodes were compared between the two groups.
resultsThe endometrial gland density and the size of the endometrial gland opening in the pregnancy group were higher than that in the non-pregnancy group (P < 0.05). In contrast, both the average pinopode count per image and the developmental maturity grading of pinopodes were significantly higher in the pregnancy group compared to the non-pregnancy group.
conclusionsBoth hysteroscopic endometrial gland image recognition technology and pinopode detection can effectively reflect endometrial receptivity and predict pregnancy outcomes. However, image recognition technology has clear economic and promotional advantages. CLINICAL TRIAL NUMBER: Not applicable.
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