ArticleBMC genomics2025
Transcriptome-based analysis reveals relationship between duck eggshell color and eggshell strength.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Genetic variants associated with reduced body size in indigenous chickens of Eritrea: A genome-wide association study.Poultry science · 2026Article
- Research Progress on Genetic Factors of Poultry Egg Quality: A Review.Animals : an open access journal from MDPI · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe strength of duck eggshells is essential for their storage, transportation, and processing, with various studies indicating a correlation between eggshell color and strength.
resultsOur research has demonstrated that green-shelled duck eggs exhibit higher eggshell strength compared to white-shelled eggs in the M2 Line Pekin Duck population. To this end, we established mRNA transcriptome profiles of 10 eggshell gland tissues and 10 liver tissues and constructed gene expression networks in the two tissues. RNA-Seq analysis suggests that genes associated with ion transport, transmembrane transport, and liver cell proliferation and differentiation in the eggshell gland could play important roles in eggshell formation. The liver of green shell duck has stronger cell proliferation ability to maintain its homeostasis, and the eggshell gland has stronger ability to secrete eggshell matrix protein, which may be the reason why the eggshell is stronger than that of white shell duck. Through Weighted gene co-expression network analysis (WGCNA), three related modules were found in eggshell gland and liver, respectively, and three key genes were screened in each tissue (eggshell gland: FKBP10, PPARG, MAP3K5, liver: PHLDA1, FLT3, CACNB4). They have important regulatory effects on eggshell color and eggshell strength respectively.
conclusionsThrough transcriptome analysis, we identified key genes associated with eggshell color (ESB) (Gland: ABCG2, SLC51B; Liver: COX1, DIO3, RBPJ) and eggshell strength (ESS) (Gland: MAP3K5, PPARG, FKBP10; Liver: PHLDA1, FLT3, CACNB4). We propose that these genes regulate ESB and ESS by modulating antioxidant capacity and bile acid synthesis in the liver and shell gland, leading to enhanced biliverdin deposition and stronger eggshells in green-shelled ducks. Additionally, the upregulation of ion transport, transmembrane transport, and liver cell proliferation-related genes in green-shelled ducks further supports the observed superiority in eggshell strength.
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