Evidence map›Paper›PMID 40295911›Full record

ArticleJournal of neurodevelopmental disorders2025

Functional connectivity between the visual and salience networks and autistic social features at school-age.

Jessica B Girault, Tomoyuki Nishino, Muhamed Talović, Mary Beth Nebel, Margaret Reynolds, Catherine A Burrows, Jed T Elison, Chimei M Lee, Abraham Z Snyder, Mark D Shen and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Jessica B GiraultCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Campus Box #3367, Chapel Hill, NC, USA. jessica_girault@med.unc.edu.
Tomoyuki NishinoDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Muhamed TalovićDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Mary Beth NebelCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.
Margaret ReynoldsDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Catherine A BurrowsDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Jed T ElisonInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Chimei M LeeDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Abraham Z SnyderDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Mark D ShenCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Campus Box #3367, Chapel Hill, NC, USA.
Audrey M ShenEaster Seals, UCP, Raleigh, NC, USA.
Kelly N BotteronDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Annette M EstesDepartment of Speech and Hearing Science, University of Washington, Seattle, WA, USA.
Stephen R DagerDepartment of Radiology, University of Washington Medical Center, Seattle, WA, USA.
Guido GerigTandon School of Engineering, New York University, New York, NY, USA.
Heather C HazlettCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Campus Box #3367, Chapel Hill, NC, USA.
Natasha MarrusDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Robert C McKinstryDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Juhi PandeyCenter for Autism Research, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Robert T SchultzCenter for Autism Research, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Tanya St JohnDepartment of Speech and Hearing Science, University of Washington, Seattle, WA, USA.
Martin A StynerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lonnie ZwaigenbaumDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Alexandre A Todorov *Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Joseph Piven *Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Campus Box #3367, Chapel Hill, NC, USA.
John R Pruett *Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
IBIS Network

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY, Natasha Marrus · 2020 to 2026
$15.5M
National Institute of Child Health and Human Development K23HD112507, R01-HD055741, T32-HD040127, P30-HD003110, P50-HD103573NICHD NIH HHS P50 HD103525NIMH NIH HHS K01-MH122779, R01-MH118362, MH118362-02S1NINDS NIH HHS P30-NS098577Simons Foundation #140209
6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) is highly heritable and phenotypically variable. Neuroimaging markers reflecting variation in behavior will provide insights into circuitry subserving core features. We examined functional correlates of ASD symptomology at school-age, while accounting for associated behavioral and cognitive domains, in a longitudinal sample followed from infancy and enriched for those with a genetic liability for ASD.

methodsResting state functional connectivity MRIs (fcMRI) and behavioral data were analyzed from 97 school-age children (8.1-12.0 years, 55 males, 15 ASD) with (n = 63) or without (n = 34) a family history of ASD. fcMRI enrichment analysis (EA) was used to screen for associations between network-level functional connectivity and six behaviors of interest in a data-driven manner: social affect, restricted and repetitive behavior (RRB), generalized anxiety, inattention, motor coordination, and matrix reasoning.

resultsFunctional connectivity between the visual and salience networks was significantly associated with social affect symptoms at school-age after accounting for all other behaviors. Results indicated that stronger connectivity was associated with higher social affect scores. No other behaviors were robustly associated with functional connectivity, though trends were observed between visual-salience connectivity and RRBs.

conclusionsConnectivity between the visual and salience networks may play an important role in social affect symptom variability among children with ASD and those with genetic liability for ASD. These findings align with and extend earlier reports in this sample of the central role of the visual system during infancy in ASD.

Indexed as

Autism Spectrum DisorderBrainNerve NetSocial BehaviorChildFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleNeural PathwaysAutismBrain networksFunctional connectivityMRISocial behavior

Identifiers

PMID40295911
PMCPMC12036130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.