ArticleThe journal of headache and pain2025
Migraine and increased cardiovascular disease risk: interaction with traditional risk factors and lifestyle factors.
Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Migraine and pregnancy-related headaches as a risk factor for cardiovascular and cerebrovascular events in pregnancy: a systematic review and meta-analysis of over 94 million pregnancies.The journal of headache and pain · 2025Pooled it
- Genetic Basis of the Negative Response to the Use of Triptans for the Treatment of Migraine-A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Smoking in primary headaches - a systematic review and meta-analysis.The journal of headache and pain · 2025Pooled it
- Review
- Migraine and Cardiovascular Risk: A Scoping Review of Vascular Outcomes, Risk Assessment, and Endothelial Dysfunction.Life (Basel, Switzerland) · 2026Review
- Evaluation of Atrial and Ventricular Myocardial Repolarization Markers During Acute Migraine Attack.Journal of clinical medicine · 2026Article
- Impact of migraine on quality of life and disability: a matched cross-sectional comparative study in a tertiary hospital in Malaysia.Frontiers in neurology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
backgroundMigraine has been linked to a heightened risk of cardiovascular disease, and acute treatment drugs, such as triptans, might increase this risk. This study aimed to determine whether the elevated cardiovascular risk is primarily attributable to the underlying migraine condition or the treatment modalities utilized. Additionally, we investigated the effects of managing traditional cardiovascular risk factors and the influence of healthy lifestyle scores on this association.
methodsThis population-based investigation leveraged data from the UK Biobank, encompassing participants recruited between 2006 and 2010, to examine the association between migraine and the long-term risk of atherosclerotic cardiovascular disease and its subtypes. Cox proportional hazard models were employed to conduct this analysis. Furthermore, the study evaluated the relative importance of migraine in predicting atherosclerotic cardiovascular disease by calculating the R² values of the Cox models. Additionally, multiplicative and additive interaction analyses were conducted to examine whether the association between migraine and cardiovascular disease varies based on the degree of risk factor control and lifestyle scores.
resultsAcross an average follow-up span of 12.9 years, a total of 24,038 cardiovascular events were documented, comprising 12,451 cases of coronary heart disease, 3,608 cases of ischemic stroke, and 4,493 cases of peripheral artery disease. In a thoroughly adjusted analysis, individuals with migraine demonstrated an increased risk of atherosclerotic cardiovascular disease, with a hazard ratio of 1.12 (95% confidence interval: 1.05 to 1.20) compared to those without migraine, indicating a significant trend (P
conclusionA significant interaction exists between unhealthy lifestyles and migraine, where their combined effects may contribute to an elevated risk of cardiovascular diseases, potentially amplifying the impact of each factor. Developing effective lifestyle intervention strategies tailored for migraine patients could help improve their long-term cardiovascular health, emphasizing the importance of comprehensive risk management.
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