ReviewNature reviews. Neuroscience2025
Interictal network dysfunction and cognitive impairment in epilepsy.
Review in Nature reviews. Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Epilepsy as a predictor of subjective memory and executive dysfunction in American children and adults, with sleep as a relevant factor.Epilepsy & behavior : E&B · 2026Article
- A pontomesencephalic-mesolimbic circuit modulates activity-based anorexia.Science advances · 2026Article
- Assessing cognitive impairment in epilepsy using Arterial spin-labeled (ASL) perfusion imaging.Brain imaging and behavior · 2026Article
- Article
- Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery.Epilepsia · 2026Article
- Clinical application of artificial intelligence technology in epilepsy.Acta epileptologica · 2026Review
- Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy.Epilepsia · 2026Article
- Implantable bioelectronic outlet.Science advances · 2026Article
- Review
- Resting-state EEG markers of cognitive dysfunction in epilepsy: evidence from gamma power, alpha activity, and functional connectivity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Association of Healthy Eating Index-2020 scores and its components with epilepsy in US adults: a cross-sectional study of NHANES 2005-2020.BMC neurology · 2026Article
- Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation.PloS one · 2026Article
- Multistage sleep recordings: a missing piece in the puzzle of human interictal single-neuron dynamics.Brain communications · 2026Article
- States of dynamic connectivity flow in temporal multiplex networks: A case study in human epilepsy and postictal aphasia.Network neuroscience (Cambridge, Mass.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is diagnosed when neural networks become capable of generating excessive or hypersynchronous activity patterns that result in observable seizures. In many cases, epilepsy is associated with cognitive comorbidities that persist between seizures and negatively impact quality of life. Dysregulation of the coordinated physiological network interactions that are required for cognitive function has been implicated in mediating these enduring symptoms, but the causal mechanisms are often elusive. Here, we provide an overview of neural network abnormalities with the potential to contribute to cognitive dysfunction in epilepsy. We examine these pathological interactions across spatial and temporal scales, additionally highlighting the dynamics that arise in response to the brain's intrinsic capacity for plasticity. Understanding these processes will facilitate development of network-level interventions to address cognitive comorbidities that remain undertreated by currently available epilepsy therapeutics.
Indexed as
Identifiers
40295879What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.