ArticleScientific reports2025
Computational intelligence modeling and optimization of small molecule API solubility in supercritical solvent for production of drug nanoparticles.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Accelerating supercritical pharmaceutical formulation via interpretable data-driven prediction of drug solubility.Scientific reports · 2026Article
- Data-driven modeling of supercritical CO₂ processing with optimized machine learning: prediction of clobetasol propionate solubility.Frontiers in medicine · 2026Article
- Utilization of sequential model-based optimizer integrated machine learning models in correlation of famotidine solubility in supercritical carbon dioxide.Scientific reports · 2025Article
- Machine learning analysis of drug solubility via green approach to enhance drug solubility for poor soluble medications in continuous manufacturing.Scientific reports · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artificial Intelligence (AI) is applied in this research for the analysis of a novel green method for production of nanomedicine. The method is based on supercritical solvent for production of drug nanoparticles in which the AI was used to estimate the solubility of drug in the supercritical solvent. Carbon dioxide was considered as the supercritical solvent in this study and the effect of pressure and temperature on the drug solubility was evaluated using the developed AI-based models. The aim here is to model and analyze the solubility of Clobetasol Propionate (CP) based on two key parameters: temperature and pressure. Ensemble models based on decision tree are selected to make models. The models include gradient boosting (GBDT), extremely randomized trees (ET), and random forest (RF) and tuned using ant colony optimization (ACO). Final models have acceptable results, all with R
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Registered trials
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