Evidence map›Paper›PMID 40295699›Full record

ArticleNpj viruses2024

Genome sequencing identifies "Limestone Canyon virus" as Montaño virus (Hantaviridae: Orthohantavirus montanoense) circulating in brush deermice in New Mexico.

Samuel M Goodfellow, Robert A Nofchissey, Valerie J Morley, Kathryn E Coan, Kurt C Schwalm, Joseph A Cook, Jonathan L Dunnum, Diane Hanfelt-Goade, Darrell L Dinwiddie, Daryl B Domman and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Characterization of the gut microbiome of wildFrontiers in microbiomes · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samuel M GoodfellowCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Robert A NofchisseyCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Valerie J MorleyCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Kathryn E CoanMuseum of Southwestern Biology, Biology Department, University of New Mexico, Albuquerque, NM, USA.
Kurt C SchwalmDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Joseph A CookMuseum of Southwestern Biology, Biology Department, University of New Mexico, Albuquerque, NM, USA.
Jonathan L DunnumMuseum of Southwestern Biology, Biology Department, University of New Mexico, Albuquerque, NM, USA.
Diane Hanfelt-GoadeDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Darrell L DinwiddieDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Daryl B DommanCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Jerry W DragooMuseum of Southwestern Biology, Biology Department, University of New Mexico, Albuquerque, NM, USA.
Jens H KuhnIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD, USA.
Steven B BradfuteCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. sbradfute@salud.unm.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orthohantaviruses infect distinct eulipotyphlan and rodent reservoirs throughout the world; some rodent orthohantaviruses can cause disease in humans. In the United States, a primary rodent reservoir for the human-pathogenic Sin Nombre virus (SNV) is the western deermouse (Peromyscus sonoriensis; formerly included in Peromyscus maniculatus). Deermice (rodents of genus Peromyscus) carry presumably distinct orthohantaviruses but, although deermice of ten species have been recorded in New Mexico, only SNV has been reported in rodents from that state. Using a set of pan-orthohantavirus primers, we discovered a non-SNV orthohantavirus in a brush deermouse (P. boylii), trapped in central New Mexico in 2019. Sequencing enabled the generation of a consensus coding-complete genome sequence, revealing similarity to the known partial sequences of the unclassified "Limestone Canyon virus (LSCV)" in GenBank and aligning with the information in an unpublished study of wild-caught brush deermice trapped in southwestern New Mexico in 2006. Phylogenetic analysis of these combined data revealed geospatial clades and overall identity of "LSCV", uncovering its association with the classified Montaño virus (MTNV), which is known to infect Aztec and Orizaba deermice in central Mexico. Our work emphasizes the importance of determining coding-complete viral genome sequences as a framework for rigorous virus classification as the basis for epidemiological studies.

Identifiers

PMID40295699
PMCPMC11721154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.