ArticleScientific reports2025
Curcumin attenuates neuroinflammation and improves cognitive function in a rat model of febrile convulsions.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effects of Curcumin on Vascular Endothelial Function, Lipid Metabolism, Inflammation and Neuroprotection-A Review.Nutrients · 2026Pooled it
- Anti-Inflammatory and Antioxidant Properties ofInternational journal of molecular sciences · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This study aimed to investigate the effects of curcumin on neuroinflammation and cognitive function in a rat model of febrile convulsions (FC). This study was conducted on 10-day-old male Wistar rat pups, randomly assigned to four groups: Control, Curcumin, FC, and FC + Curcumin. FC were induced by placing the rats in a 44 °C water bath until convulsions occurred or for a maximum of 4 min. Curcumin (200 mg/kg/day) was administered intraperitoneally for seven consecutive days before FC induction. Neuroinflammation was assessed by measuring hippocampal and serum TNF-α and IL-1β levels using ELISA. Cognitive function was evaluated using the Morris Water Maze (MWM) test, where escape latency, swimming speed, and distance traveled were recorded, followed by a probe test on Day 5 to assess memory retention. Motor coordination was assessed using the Rotarod test, measuring latency to fall. Curcumin treatment significantly reduced hippocampal TNF-α levels in the FC model (FC group: 145.3 ± 12.1 pg/mL vs. FC + Curcumin group: 98.6 ± 9.4 pg/mL, p = 0.001). In the MWM test, curcumin-treated rats exhibited shorter escape latencies and improved spatial memory performance compared to the FC group (p < 0.05). By Day 4, the curcumin-treated group had a significantly shorter escape latency (FC group: 42.8 ± 5.9 s vs. FC + Curcumin group: 25.3 ± 4.1 s, p = 0.002) and traveled a shorter distance to reach the platform (FC group: 335.4 ± 22.8 cm vs. FC + Curcumin group: 192.6 ± 18.3 cm, p = 0.001). Curcumin administration significantly reduced FC termination time (FC group: 96.7 ± 7.4 s vs. FC + Curcumin group: 62.5 ± 5.9 s, p = 0.001). Curcumin exerts neuroprotective effects in FC by reducing hippocampal neuroinflammation and improving cognitive function. These findings suggest that curcumin could be a promising therapeutic agent in managing febrile seizure-related neuroinflammation and cognitive dysfunction. Further studies are warranted to explore its long-term efficacy and clinical applicability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.