Observational studyScientific reports2025
A U shaped association between the HCT-ALB and hospital mortality in patients with sepsis.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of prognostic nutritional index with mortality in patients with sepsis-associated delirium: a retrospective MIMIC-IV study.BMC neurology · 2026Article
- MHR and CRP/Albumin Ratio Correlate with Wagner Grade in Diabetic Foot Ulcers: A Chinese Retrospective Study with Pathogen Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association of Hematocrit and Albumin Difference With Ventilator-Associated Pneumonia in Patients With Continuous Mechanical Ventilation: Evidence From MIMIC-IV Database.Canadian respiratory journal · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
The difference between hematocrit and serum albumin (HCT-ALB) demonstrates diagnostic significance in infectious diseases, yet the nonlinear relationship between HCT-ALB and hospital mortality in ICU patients with sepsis remains unexplored. This retrospective multicenter cohort study analyzed 7,546 ICU sepsis patients (mean age 66 ± 16 years) to elucidate the HCT-ALB-mortality relationship. Using Cox proportional hazards models with smooth curve fitting, we identified a U-shaped association: Threshold analysis revealed an inflection point at 6.1. Below this threshold, each unit HCT-ALB increase corresponded to reduced mortality risk (adjusted HR 0.986, 95%CI 0.972-0.999; P = 0.036). Conversely, values ≥ 6.1 predicted escalating risk (adjusted HR 1.048 per unit increase, 95%CI 1.037-1.060; P < 0.0001). Significant age interaction was observed (P for interaction < 0.05), with heightened mortality risk in elderly patients (≥ 65 years: HR 1.022, 95%CI 1.014-1.031). These findings establish HCT-ALB as a non-linear predictor of sepsis outcomes, emphasizing its critical threshold dynamics and age-dependent prognostic implications.
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