ArticleScientific reports2025
Differential behavior responses and genetic alteration underpinning exercise effectiveness in stress-susceptible mice.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise has differential cardiometabolic effects in male and female mice on a high-fat diet.Physiological reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Stress susceptibility varies across individuals, influenced by genetic, molecular, and environmental factors. Hence, approaches for exercise treatment as an antidepressant and anxiolytic intervention must consider individual variability. Examining individual adaptation to exercise provides insights into the biology of such variations. We investigated the efficacy of voluntary wheel running (VWR) exercise as a disease-modifying treatment for stress-susceptible (SS) mice subjected to chronic restraint stress. A multidimensional behavior analysis revealed significant variability in VWR efficacy among individuals; while some mice showed substantial behavior phenotypic improvements (SES), others displayed limited/no benefits (SER). A transcriptomic profiling of the ventral hippocampus, a brain region critical to emotional regulation, revealed molecular signatures that promote adaptive changes by restoring cellular repair, energy availability, and synaptic plasticity in SS mice. SER mice exhibited limited behavior resilience and distinct transcriptomic profiles enriched in structural adaptation without functional resilience and glial cell differentiation marked by astrocyte activation or differentiation. These findings suggest that while VWR can mitigates multiple behavior symptoms in stress-susceptible mice, its effectiveness is modulated by distinct biological mechanisms. We highlight the importance of a multivariate framework for behavior assessment and genetic underpinnings, clarifying the variability in responses to stress and exercise's therapeutic efficacy in stress-related disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.