ArticleNPJ biofilms and microbiomes2025
Multi-omics approach identifies gut microbiota variations associated with depression.
Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Integrated metagenomic and metabolomic analysis identifies severity-specific inflammatory and metabolic signatures in post-stroke depression.Gut microbes · 2026Article
- Deciphering the Link Between Gut Bacterial Community Structure of Forest Musk Deer (Veterinary sciences · 2026Article
- Gut Microbiota and Metabolites: Orchestrating Depression Pathogenesis Through the Microbiota-Gut-Brain Axis's Neural, Immune, and Metabolic Routes.Biomolecules · 2026Review
- Reproducible Gut Microbiome Alterations in Major Depressive Disorder: A Systematic Review of Taxonomic and Functional Findings.Epidemiologia (Basel, Switzerland) · 2026Review
- Mental health in early pregnancy: Interplay of objectively measured lifestyles, gut microbiota, and metabolomics.iScience · 2026Article
- Complex correlations between mitochondrial DNA variants and gut microbiome in major depressive disorder: a genome-wide association analysis.BMC psychiatry · 2026Article
- Sex differences in behaviors, neuronal activation, and gut-microbiota-metabolic axis in a repeated nitroglycerin-induced chronic migraine model.The journal of headache and pain · 2026Article
- Gut-brain axis in health and brain disease.Chinese medical journal · 2026Review
- Novel insights into how gestational diet affects maternal-infant microbiota: a cross-sectional causal mediation analysis at one month postpartum.European journal of nutrition · 2026Observational
- Fecal metaproteomics reveals alterations in gut microbiota and intestinal proteins in adolescents with bipolar depression.Translational psychiatry · 2026Article
- Interplay of Microbiome, Oxidative Stress and Inflammation in Health and Disease.Antioxidants (Basel, Switzerland) · 2026Review
- Gut Microbiota Dysbiosis in Depression: Pathological Correlations, Molecular Pathways, and Therapeutic Interventions.International journal of molecular sciences · 2026Review
- The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression.MedComm · 2026Article
- From mitochondrial oxidative stress to neuroinflammation: integrated proteomic and transcriptomic profiling reveals the role of the ROS/TXNIP/NLRP3 signaling pathway in anxious depression.Frontiers in immunology · 2026Article
- Intestinal microbial remodeling and metabolite regulation may be related to the improvement of social avoidance in depressed mice by Modified Xiaoyaosan.Frontiers in microbiology · 2026Article
- Pharmaco-multiomics in major depressive disorder: a narrative review and proposed translational framework for difficult-to-treat and treatment-resistant depression.Frontiers in pharmacology · 2026Review
- Tryptophan metabolism: a critical bridge linking gut microbiota to depression.Frontiers in microbiology · 2026Review
- Microbiome driven modulation of neurotransmitters: implications for neurotransmission and mood disorders.Frontiers in microbiology · 2026Review
- A Novel Integrative Framework for Depression: Combining Network Pharmacology, Artificial Intelligence, and Multi-Omics with a Focus on the Microbiota-Gut-Brain Axis.Current issues in molecular biology · 2025Review
- Multi-Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome.Journal of periodontal research · 2025Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
The gut microbiota plays a potential role in the pathophysiology of depression through the gut-brain axis. This cross-sectional study in 400 participants from the PREDIMED-Plus study investigates the interplay between gut microbiota and depression using a multi-omics approach. Depression was defined as antidepressant use or high Beck Depression Inventory-II scores. Gut microbiota was characterized by 16S rRNA sequencing, and faecal metabolites were analysed via liquid chromatography-tandem mass spectrometry. Participants with depression exhibited significant differences in gut microbial composition and metabolic profiles. Differentially abundant taxa included Acidaminococcus, Christensenellaceae R-7 group, and Megasphaera, among others. Metabolomic analysis revealed 15 significantly altered metabolites, primarily lipids, organic acids, and benzenoids, some of which correlated with gut microbial features. This study highlights the interplay between the gut microbiota and depression, paving the way for future research to determine whether gut microbiota influences depression pathophysiology or reflects changes associated with depression.
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