ArticleScientific reports2025
An African swine fever vaccine-like variant with multiple gene deletions caused reproductive failure in a Vietnamese breeding herd.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A dual-gene-deleted ASFV Lv17/WB/Rie1-ΔCD candidate administered orally to wild boar confers DIVA-compatible protection against virulent challenge.The veterinary quarterly · 2026Article
- Live-attenuated African swine fever vaccine HLJ/18-7GD is safe in pregnant sows with no impact on reproductive performance or offspring health at a field farm.Emerging microbes & infections · 2026Article
- Distinct cytotoxic cell subsets underlie protective and non-protective immunity to African swine fever virus.Emerging microbes & infections · 2026Article
- Hybrid genotype I and II ASFVEmerging microbes & infections · 2026Article
- African swine fever in the era of global expansion: Epidemiology, transmission dynamics, viral evolution, and One Health control strategies.Veterinary world · 2026Review
- Dual Antiviral Functions of Antibodies Targeting African Swine Fever Virus p17 Protein: Viral Inhibition and ADCC Induction.Viruses · 2026Article
- Exploiting Ubiquitination: African Swine Fever Virus-Mediated Recruitment of Host E3 Ligases During Viral Infection and Immune Regulation.Pathogens (Basel, Switzerland) · 2026Review
- Current Insights into the Epidemiology and Transmission Dynamics of African Swine Fever Virus and Future Control Perspectives.Pathogens (Basel, Switzerland) · 2026Review
- Article
- Adjuvant-induced macrophage activation compromises BA71ΔCD2-mediated protection against African swine fever virus.NPJ vaccines · 2026Article
- The Prospects and Challenges of Live Attenuated Vaccines Against African Swine Fever Virus in Vietnam.Vaccines · 2026Review
- Establishment and characterization of a replication-restricted modified African swine fever virus.Microbiology spectrum · 2026Article
- Recombinant vaccinia vectored ASFV vaccine enhances swine survival against genotype II challenge.NPJ vaccines · 2026Article
- Subtle Genetic Shifts of African Swine Fever Virus Among Vietnamese Domestic Swine Following Live-Attenuated Vaccine Commercialization.Transboundary and emerging diseases · 2026Article
- African swine fever control in the context of endemic persistence.Frontiers in veterinary science · 2026Article
- First detection of African swine fever in a swine farm in Taiwan.Frontiers in veterinary science · 2026Article
- Live Attenuated Vaccines for African Swine Fever: Perspectives on Their Use and Strategic Directions.Transboundary and emerging diseases · 2026Review
- Comparative epidemiology and preparedness for African swine fever and porcine reproductive and respiratory syndrome in four major Asian swine industries.Frontiers in veterinary science · 2026Review
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
African swine fever (ASF), an economically damaging disease in domestic pigs, has emerged in Vietnam since 2019. Vietnam is the only country granted licenses for developing and commercializing modified live-attenuated vaccines (LAVs) against the highly pathogenic ASF virus (ASFV). The nationwide implementation of LAVs in Vietnam for prophylaxis has likely influenced the viral genetic pool among the swine population. This study highlighted the incursion of a novel ASF vaccine-like variant into a non-vaccinated breeding herd. Retrospective epidemiology suggested a high replacement rate and improper biosecurity measures might introduce the disease into the herd. Affected gilts displayed non-to-mild symptoms, whereas gestational sows experienced reproductive disorders. Remarkably, severe ulcerative dermatitis in udders was observed in lactating sows 1-2 weeks postpartum. The ASF outbreak was significantly associated with reduced reproductive performance compared to the pre-outbreak period (P < 0.001). Genetic analysis revealed several virulence-associated gene deletions and a marker gene presence in the left variable region, consistent with the ASFV-G-∆MGF vaccine strain. Molecular detection and immunohistochemistry indicated viral antigens distributed in macrophage-like cells of the reproductive organs and affected udders. Microscopic findings implied massive necrotizing vasculitis with fibrinoid degeneration compatible with immune complex-induced lesions. In conclusion, naïve sows are highly susceptible to the novel ASF vaccine-like variant than gilts, underscoring improved biosecurity requirements when introducing replacement gilts and monitoring ASF vaccine-like variants.
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