ArticleScientific reports2025
The association between upper tarsal conjunctiva appearance and corneal biomechanical weakening in refractive surgery candidates.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Current evidence suggests allergic conjunctivitis and contact lens use may affect corneal biomechanics, but the relationship between conjunctival changes and biomechanical abnormalities remains unclear. This study aimed to determine whether upper tarsal conjunctival roughness and redness are associated with corneal biomechanical weakening in refractive surgery candidates without ectatic corneal disease. Conducted at Chiang Mai University LASIK Center between July 2023 and January 2024, conjunctival roughness and redness were graded using the Institute for Eye Research (IER) scales, while corneal biomechanics were assessed through Corvis parameters. The study included 434 eyes from 217 participants (70.5% female), with a mean age of 33.4 years (SD 8.3). Ocular allergy was reported by 23.0% (50/217) of participants, and 54.4% (236/434) had a history of contact lens use. The median conjunctival roughness score was 2 (IQR 0, 5). Conjunctival roughness score was positively correlated with biomechanical indices, particularly the deformation amplitude (DA) ratio (coefficient 0.009, 95% confidence interval 0.001 to 0.017, p = .04), suggesting weakened biomechanical property. No significant association was found between conjunctival redness and corneal biomechanics. In conclusion, upper tarsal roughness may associate with biomechanical weakening of the cornea, though these changes were insufficient to significantly affect the Corvis Biomechanical Index (CBI).
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