ReviewUpdates in surgery2025
Necrotizing soft tissue infections: a surgical narrative review.
Review in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Improving cost-efficiency in port-site fascial closure: a novel Veress-needle technique and a comprehensive literature review.Updates in surgery · 2026Article
- A Case ofClinical case reports · 2026Article
- Prognostic value of inflammatory and metabolic markers in Fournier's gangrene: a single-center retrospective analysis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Mechanisms underlying pyogenic bacterial infections of the skin.Archives of microbiology · 2026Review
- Clinical characteristics, treatment outcomes, and predictors of early mortality in Vibrio vulnificus infection in Eastern Thailand: A 6.5-year multicenter cohort study.PLoS neglected tropical diseases · 2026Article
- Results of surgical treatment of necrotizing soft tissue infections. A 15-years retrospective cohort study of a single center of emergency surgery.Langenbeck's archives of surgery · 2026Article
- Article
- Diagnostic strategies in necrotizing soft tissue infections: from clinical scores to multi-omics and machine learning.Burns & trauma · 2026Review
- Host-response trajectories in necrotizing fasciitis: host-pathogen interactions, immune evasion, and immunoparalysis.Frontiers in cellular and infection microbiology · 2026Review
- Prediction of mortality in necrotizing fasciitis: comparative evaluation of established prognostic scores and a novel scoring system in a retrospective cohort.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Automated Detection of Necrotizing Soft Tissue Infection Features by Computed Tomography.Diagnostics (Basel, Switzerland) · 2025Article
- Fulminant necrotizing fasciitis secondary toFrontiers in medicine · 2025Article
- Case Report: From septic shock to recovery - a battle against lethal necrotizing soft tissue infection.Frontiers in immunology · 2025Article
- Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy.Frontiers in chemistry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing soft tissue infections represent a spectrum of diseases characterized by extensive necrosis involving the skin, subcutaneous tissues, fascia or muscles. These infections are generally severe and rapidly progressive, often accompanied by sepsis, septic chock, multiple organ failure and, ultimately, death. Several classifications have been developed based on multiple parameters, such as the anatomical location of the disease, the depth of the lesion or the microbiology. Numerous clinical factors predispose individuals to the development of necrotizing soft tissue infections. The clinical presentation is not always characterized by local signs and systemic symptoms of infection, which can lead to delays in both diagnosis ad treatment. Broad-spectrum antibiotic directed at the likely organisms is essential early in the treatment course, but do not substitute surgical management. Antibiotic therapy should be subsequently tailored to the etiologic micro-organism. Rapid recognition and early surgical intervention form the mainstay of management of necrotizing soft tissue infections. Initial surgical debridement should be promptly performed preferably at the presenting hospital, when adequate infrastructure and personnel are available. Transfer to a referral center may be necessary for definitive surgical and complex wound care. Most patients require more than one debridement. A multidisciplinary approach is also essential to improve the results in the treatment of these patients.
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