Evidence map›Paper›PMID 40295384›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Factors associated with significant improvement in cancer-related fatigue after completing cognitive behavioral therapy for insomnia in cancer survivors.

Krista M Greeley, Joshua Rash, Joshua Tulk, Josée Savard, Melanie Seal, Robin Urquhart, John Thoms, Kara Laing, Emily Fawcett, Sheila N Garland

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04026048 (A Randomized Controlled Trial of Online Cognitive Behavior Therapy for Insomnia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04026048 nacompletednot on this map

A Randomized Controlled Trial of Online Cognitive Behavior Therapy for Insomnia (CBT-I) and Perceived Cognitive Impairment (PCI) in Cancer Survivors

TypeinterventionalSponsorMemorial University of NewfoundlandRan2019 to 2023Enrolled132ConditionsCancer, Insomnia, Cognitive ImpairmentArmsCognitive Behaviour Therapy for Insomnia (CBT-I)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Krista M GreeleyDepartment of Psychology, Faculty of Science, Memorial University, 232 Elizabeth Ave, St. John's, NL, A1B 3X9, Canada.ORCID http://orcid.org/0009-0007-6076-8563
Joshua RashDepartment of Psychology, Faculty of Science, Memorial University, 232 Elizabeth Ave, St. John's, NL, A1B 3X9, Canada.ORCID http://orcid.org/0000-0003-0927-0712
Joshua TulkDepartment of Psychology, Faculty of Science, Memorial University, 232 Elizabeth Ave, St. John's, NL, A1B 3X9, Canada.ORCID http://orcid.org/0000-0001-9908-263X
Josée SavardSchool of Psychology, Université Laval, CHU de Québec-Université Laval Research Center, , Quebec City, QC, Canada.ORCID http://orcid.org/0000-0002-8052-1046
Melanie SealDiscipline of Oncology, Faculty of Medicine, Memorial University, St. John's, NL, Canada.
Robin UrquhartDepartment of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0001-8864-5716
John ThomsDiscipline of Oncology, Faculty of Medicine, Memorial University, St. John's, NL, Canada.
Kara LaingDiscipline of Oncology, Faculty of Medicine, Memorial University, St. John's, NL, Canada.
Emily FawcettDepartment of Psychology, Faculty of Science, Memorial University, 232 Elizabeth Ave, St. John's, NL, A1B 3X9, Canada.ORCID https://orcid.org/0000-0002-4734-974X
Sheila N GarlandDepartment of Psychology, Faculty of Science, Memorial University, 232 Elizabeth Ave, St. John's, NL, A1B 3X9, Canada. sheila.garland@mun.ca.ORCID http://orcid.org/0000-0002-6119-318X

Funding

Canadian Cancer Society 707146Canadian Cancer Society 707939CIHR PJT 162428
6 · The paper itself

Abstract

purposeCancer-related fatigue (CRF) can be a persistent and severe consequence of cancer treatment. Cognitive behavioral therapy for insomnia (CBT-I) can improve CRF in those with insomnia comorbid with cancer. This secondary analysis of a randomized controlled trial investigated what proportion of participants benefit and the factors associated with an improvement in CRF following CBT-I.

methodsAtlantic Canadian cancer survivors (N = 121) with insomnia disorder and perceived cognitive impairment symptoms were recruited to participate in a randomized controlled trial of CBT-I. Fatigue was measured using the Multidimensional Fatigue Symptom Inventory-Short Form. Univariable and multivariable binary logistic regressions were used to assess clinical, symptom, and demographic factors associated with a significant improvement in CRF after CBT-I.

resultsThe majority (75%) of the sample (M

conclusionCBT-I can effectively reduce CRF in cancer survivors who also experience insomnia. Differences in sleep patterns and/or the number of comorbid physical health concerns between younger and older people may explain why CBT-I improved CRF more in younger participants. Future research is needed to better understand the demographic, symptom, and clinical variables that may influence treatment response.

trial registrationThis is a secondary analysis of a registered randomized controlled trial (clinicaltrials.gov identifier: NCT04026048).

Indexed as

Cancer SurvivorsCognitive Behavioral TherapyFatigueNeoplasmsSleep Initiation and Maintenance DisordersAdultAgedAge FactorsAnxietyCanadaFemaleHumansMaleMiddle AgedSex FactorsCancerCancer-related fatigueCognitive behavioral therapy for insomniaInsomnia

Identifiers

PMID40295384

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.