Evidence map›Paper›PMID 40295318›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Effects of L-glutamine and hyaluronic acid associated with photobiomodulation on oral mucositis: a randomized clinical trial.

Rodrigo Wilmes Dos Santos, Allisson Filipe Lopes Martins, Sebastião Silvério Sousa-Neto, Marília Oliveira Morais, Victor Hugo Lopes de Oliveira Moreira, Diego Antonio Costa Arantes, Angélica Ferreira Oton-Leite, Nilceana Maya Aires Freitas, Cláudio Rodrigues Leles, Elismauro Francisco Mendonça

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rodrigo Wilmes Dos SantosUniversidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP: 74605 - 220, Brazil.
Allisson Filipe Lopes MartinsUniversidade Evangélica de Goiás, Dentistry School, Av. Universitária, S/N - Cidade Universitária, Anápolis, Goiás, CEP: 75083 - 515, Brazil.
Sebastião Silvério Sousa-NetoLaboratory of Oral Pathology, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP: 74605 - 220, Brazil.
Marília Oliveira MoraisAraujo Jorge Cancer Hospital. R. 239, 206 - Setor Universitário, Goiânia, Goiás, CEP: 74175 - 120, Brazil.
Victor Hugo Lopes de Oliveira MoreiraLaboratory of Oral Pathology, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP: 74605 - 220, Brazil.
Diego Antonio Costa ArantesLaboratory of Oral Pathology, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP: 74605 - 220, Brazil.
Angélica Ferreira Oton-LeiteAraujo Jorge Cancer Hospital. R. 239, 206 - Setor Universitário, Goiânia, Goiás, CEP: 74175 - 120, Brazil.
Nilceana Maya Aires FreitasDepartment of Radiotherapy, Araujo Jorge Cancer Hospital, R. 239, 206-Setor Universitário, Goiânia, Goiás, CEP 74175 - 120, Brazil.
Cláudio Rodrigues LelesDepartment of Prevention and Oral Rehabilitation, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP 74605 - 220, Brazil.
Elismauro Francisco MendonçaSchool of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP 74605 - 220, Brazil. elismaur@ufg.br.

Funding

Brazilian National Council for Scientific and Technological Development - CNPq 307906-7Fundação de Amparo à Pesquisa do Estado de Goiás 201710267001233
6 · The paper itself

Abstract

objectiveTo investigate whether the application of L-glutamine (L-G) and hyaluronic acid (HA) associated with photobiomodulation (PBM) and the Preventive Oral Care Protocol (POCP) would present similar efficacy as the exclusive use of PBM, associated with POCP, in the prevention and control of severe oral mucositis (OM). STUDY

designPatients with head and neck cancer undergoing radiochemotherapy (RCT) were randomized into two groups: group A, patients that received PBM + POCP (n = 24), and group B, patients that received PBM + POCP + L-G + HA (n = 24). OM was assessed using the National Cancer Institute (NCI) and World Health Organization (WHO) scales. The impact of oral health on patients' quality of life and perception of OM symptoms was evaluated. Assessments were made at the 1st, 7th, 14th, 21st, and 30th radiotherapy (RT) sessions.

resultsWhen the severity of OM was assessed according to the WHO scale in the 30th RT, group B showed lower rates of severe OM than group A. There were no differences when using the NCI scale. The impact of oral health on quality of life and the symptoms reported by patients were lower in group B at all times evaluated.

conclusionThe combination of PBM + POCP + L-G + HA resulted in a significantly lower severity of OM than PBM + POCP alone, according to the WHO scale at the 30th RT.

trial registrationBrazilian Clinical Trials Registry-REBEC no. RBR-6ybmgcv. Registration March 27, 2022.

Indexed as

GlutamineHead and Neck NeoplasmsHyaluronic AcidLow-Level Light TherapyStomatitisAdultAgedChemoradiotherapyFemaleHumansMaleMiddle AgedQuality of LifeSeverity of Illness IndexGlutamineHyaluronic AcidGlutamineHead and neck cancerHyaluronic acidOral mucositisPhotobiomodulation therapyRadiotherapy

Identifiers

PMID40295318

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.